Results 41 to 50 of about 44,776 (142)
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells [PDF]
, 2014 Aims In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such as proliferation, angiogenesis, invasion and metastasis. These effects are dependent by the
Bagnato, Anna +6 more
core +1 more source
Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death
Cell Death Discovery, 2022 Endothelin (EDN, also known as ET) signaling has been suggested to be an important mediator of retinal ganglion cell (RGC) death in glaucoma. Antagonism of EDN receptors (EDNRA and EDNRB, also known as ET-A and ET-B) prevented RGC death in mouse models ...
Olivia J. Marola +2 more
doaj +1 more source
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]
, 2012 Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed +62 more
core +2 more sources
مجله دانشکده پزشکی اصفهان, 2018 Background: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is one of the predominant sources of the production of free oxygen radicals in the vascular wall.
Parisa Dayati +3 more
doaj +1 more source
Endothelin receptor antagonism and cancer [PDF]
European Journal of Clinical Investigation, 2009 AbstractThe endothelin peptides have an important role in the cancer‐stromal interactions that promote tumour growth. Endothelin‐1 (ET‐1), clinically the most investigated endothelin, is a vital agent in the growth and progression of several tumours including prostate, ovarian, colorectal, bladder, breast and lung carcinomas.
Marc C. Winslet +4 more
openaire +3 more sources
Examining the role of insulin in the regulation of cardiovascular health [PDF]
, 2013 A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
Endothelin type A receptors mediate pain in a mouse model of sickle cell disease
Haematologica, 2018 Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease.
Brianna Marie Lutz +7 more
doaj +1 more source
Pulmonary Circulation, 2020 Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited.
Robert P. Frantz +6 more
doaj +1 more source
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]
, 2009 Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Alan A. Okada +7 more
core +1 more source