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Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-Oncology, 1997
The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB-1). Neuregulins consist of a large
M, Westphal   +7 more
openaire   +2 more sources

Structural analysis of the ErbB‐2 receptor using monoclonal antibodies: Implications for receptor signalling

International Journal of Cancer, 2003
AbstractThe extracellular part of ErbB‐2 is formed by 4 domains, specifically, L1, L2 that adopt a β‐helical structure and S1, S2 that consist of several cysteine‐rich, EGF‐fold modules. These ectodomains mediate ErbB‐2 dimerisation with itself or with other members of the epidermal growth factor receptor (EGFR) family, events essential to both ErbB‐2 ...
Yip, YL   +3 more
openaire   +3 more sources

Dynamics of the transmembrane domain of the ErbB-2 receptor

Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta), 1999
The structure and dynamics of the ErbB-2 transmembrane domain have been examined using molecular dynamics techniques both in vacuum and within an explicit hydrated L-α-dilauroyl-phosphatidyl-ethanolamine environment. In-vacuum simulations show that a highly cooperative structural transition occurs frequently within the α-helical transmembrane domain ...
Jean-Pierre Duneau   +3 more
openaire   +1 more source

c-erbB-2 Oncoprotein and Epidermal Growth Factor Receptor in Cervical Lesions

Pathobiology, 1997
Epidermal growth factor receptor (EGF-R) and the oncogene product of c-erbB-2 have been shown to be expressed in human tumors and in some cases relate to clinical outcome. This study investigates the correlation between the presence of these receptor proteins and various histological grades of cervical tissues.
S, Lakshmi   +5 more
openaire   +2 more sources

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