Results 121 to 130 of about 85,930 (259)

Calycosin Targets the CYP1B1‐AKT/SP1‐GPX4 Axis to Modulate Ferroptosis in Colorectal Carcinogenesis

Phytotherapy Research, EarlyView.
Mechanism of Calycosin in Regulating Ferroptosis in Colorectal Cancer via Binding to CYP1B1. ABSTRACT Calycosin, a natural flavonoid small‐molecule compound derived from traditional Chinese medicine, has demonstrated remarkable pharmacological activity in the field of cancer therapy.
Lihan Bie, Xin Lei, Di Wu, Yang Zhang, Chengshan He, Luyao Liu, Jiawei Zhou, Xin Zhou, Yingying Lu, Zheng Xu   +9 more
wiley   +1 more source

Type 1 insulin-like growth factor receptor (IGF-1R) targeted therapies in pediatric cancer

Frontiers in Oncology, 2013
Data from over 20 years ago demonstrated potential use for IGF signaling modulators, specifically with IGF-1R antagonists, in a variety of pediatric and adolescent cancers, particularly in sarcomas. However, in spite of promising preclinical data, IGF-1R inhibitors have not had the success as single agents that was originally hoped for in clinical ...
Michael J Wagner, Robert G Maki
openaire   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling. [PDF]

Cancers (Basel)
Suba Z.
europepmc   +1 more source

Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Insulin‐like growth factor 1 receptor (IGF‐1R) is crucial for immunological control and the development of different types of cancer. It is still uncertain how the expression of IGF‐1R impacts hypopharyngeal squamous cell carcinoma (HPSCC) and whether it has any predictive value for prognosis.
Wen‐Jing Li, Xiao‐Lin Xu, Li‐Cheng Xu, Shun‐Peng Wang, Yao‐Yao Dong, Yi Wang, Xiao‐Li Ren, Lei Ye, Peng‐Yan Liu, Ming Liu, Lin‐Li Tian   +10 more
wiley   +1 more source

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +1 more source

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source