Beyond Insulin Resistance: Exploring the Centrality of the Gut-Liver Axis in Mediating Immunometabolic Dysregulation Driving Hepatocellular Carcinoma in MASLD and Diabetes. [PDF]
Romeo M +10 more
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Lifestyle intervention based on aerobic exercise and Mediterranean diet modulates IGF-1 and its binding proteins in breast cancer survivors. [PDF]
Annibalini G +16 more
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To test or not to test: what we have learnt from 50 years of dynamic testing in acromegaly. [PDF]
De Marinis L +7 more
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Physical Exercise Enhances Melatonin Effect in D-Galactose/Aluminum Chloride-Induced Alzheimer's Disease of Ovariectomized Rats: Irisin Induction Associated with Upregulation of PPAR-γ/IGF-1/BDNF and Decreasing TNF-α/p38-MAPK/NLRP3/GFAP Pathway. [PDF]
Badawi GA +5 more
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Type 1 IGF receptor in human breast diseases
Breast Cancer Research and Treatment, 1992The first step of the action of IGF1 and IGF2 (IGFs) is their binding to membrane receptors. IGF binding sites have been characterized by competitive binding and cross-linking techniques in human breast cancer cell lines as well as in human breast cancers and in human benign breast diseases.
J P, Peyrat, J, Bonneterre
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Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor
Regulatory Peptides, 1996The hydrophobic residue Phe-23 lies on a surface of insulin like growth factor 1 (IGF-1) which may be involved in binding to the type I IGF and insulin receptors. The possibility that Phe-23 participates directly in binding to these receptors has been investigated by comparing the properties of [F23G]IGF-1, a mutant of insulin-like growth factor 1 in ...
D R, Hodgson, F E, May, B R, Westley
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P46 Studies on the bivalent interaction of IGF-II with the insulin and type 1 IGF receptors
Growth Hormone & IGF Research, 2010demonstrated the role of the IGF system in the regulation of trophoblast proliferation and survival and alterations in the IGF ligands or the receptors could have implications in the pathogenesis of trophoblastic diseases. The aim of this study was to investigate the role of the IGF system in trophoblast cell differentiation by evaluating the ...
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