Results 231 to 240 of about 89,239 (242)

Gene expression of insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation

Endocrinology, 1992
Altered gene expression and/or actions of the insulin-like growth factors (IGFs) have been implicated in the mediation of both pre- and postnatal growth retardation secondary to glucocorticoid excess. To investigate this possibility, we assessed the gene expression of the IGFs, the type I IGF receptor, and IGF-binding proteins (IGFBPs) in 20-day ...
W A, Price, A D, Stiles, B M, Moats-Staats, A J, D'Ercole   +3 more
openaire   +3 more sources

Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

Journal of Molecular Endocrinology, 1996
ABSTRACT Insulin-like growth factor-I (IGF-I) analogues were produced with the aim of identifying IGF-I residues that contribute to the specificity of binding to the type 1 IGF receptor as opposed to the insulin receptor. Receptor binding properties of a series of A- and B-domain analogues were compared using rat L6 myoblasts, soluble human IGF type 1 ...
G K, Shooter, B, Magee, M A, Soos, G L, Francis, K, Siddle, J C, Wallace   +5 more
openaire   +2 more sources

Regulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles

Journal of Endocrinology, 1996
Abstract The relative abundance and location of type 1 IGF receptors in sheep muscles have been measured to determine whether changes occur during post-natal growth and nutritional stress. Using the technique of histological autoradiography, specific binding of 125I-IGF-I in muscle fibre and connective tissue of M.
J M, Oldham, J A, Martyn, S P, Kirk, J R, Napier, J J, Bass   +4 more
openaire   +2 more sources

Localization of Insulin and Type 1 IGF Receptors in Rat Brain by in Vitro Autoradiography and in Situ Hybridization

1991
Insulin and the insulin-like growth factors (IGFs) are structurally related, circulating hormones that regulate growth and intermediary metabolism in virtually all tissues. In many organs their function has been well defined but in the adult CNS no general understanding of their action and importance is available.
J L, Marks, M G, King, D G, Baskin
openaire   +2 more sources

Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation

Endocrine, 2009
Growth hormone (GH) and IGF-I have been implicated in the pathogenesis of type I diabetic (DM) nephropathy. We investigated renal GH receptor (GHR) and IGF-type 1 receptor (IGF1R) signaling in an animal model of type I DM. Kidney tissue was examined for GHR and IGF1R key signaling molecules.
Daniel, Landau, Renanah, Eshet, Ariel, Troib, Yotam, Gurman, Yu, Chen, Ralph, Rabkin, Yael, Segev   +6 more
openaire   +2 more sources

Detection of type 1 insulinlike growth factor (IGF) receptors in Wilms' tumors.

The American journal of pathology, 1988
Insulinlike growth factors (IGFs) are peptide hormones that regulate proliferation and differentiation of several types of normal and neoplastic cells. Recent studies of Wilms' tumor, a childhood kidney neoplasm, have detected increased expression of IGF-2 mRNA and protein.
T, Gansler, K D, Allen, C F, Burant, T, Inabnett, A, Scott, M G, Buse, D A, Sens, A J, Garvin   +7 more
openaire   +1 more source

Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity.

Endocrinology, 2001
Insulin-like growth factor binding proteins (IGFBPs) regulate the cellular actions of the IGFs owing to their strong affinities, which are equal to or stronger than the affinity of the type 1 IGF receptor (IGF-IR), the mediator of IGF signal transduction.
J M, Ricort, M, Binoux
openaire   +1 more source

Analysis of the interaction of IGF I and structural mutants of IGF I with the IGF types 1 and 2 and insulin receptors

1988
Margaret A. Cascieri, Gary G. Chicchi, Barbara G. Green, Joy Applebaum, Nancy S. Hayes, Marvin L. Bayne   +5 more
openaire   +1 more source

Regional variations of IGF-I, IGF-II and type 1 receptor in BPH.

1999
S. Monti, SCIARRA, Alessandro, TOSCANO, Vincenzo, R. Iraci, A. Tomaiuoli, C. Martini, S. Lanzara, F. Sciarra, DI SILVERIO, Franco   +8 more
openaire   +1 more source

Developmental expression of insulin‐like growth factors (IGFs) and their type 1 receptor in the chick

Biology of the Cell, 1995
Martin Holzenberger, Françoise Lapointe, Christiane Ayer‐Le Lievre   +2 more
openaire   +1 more source