Results 241 to 250 of about 35,242,900 (287)

A tissue-engineered human psoriatic skin model: targeting inflammation and glucose metabolism dysregulation in psoriasis using microneedle patches. [PDF]

Front Mol Biosci
Ruel Y, Moawad F, Cortez Ghio S, Brambilla D, Pouliot R.   +4 more
europepmc   +1 more source

A long-acting octreotide analog formed by conjugation with a peptide linker modified with two fatty acids. [PDF]

Front Endocrinol (Lausanne)
Yu YH, Chuang YS, Gehlert J, Peng CJ, Lin WC, Wong MT, Wright J, Chu HM, Lim C, Chang TW.   +9 more
europepmc   +1 more source

Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

Journal of Molecular Endocrinology, 1996
ABSTRACT Insulin-like growth factor-I (IGF-I) analogues were produced with the aim of identifying IGF-I residues that contribute to the specificity of binding to the type 1 IGF receptor as opposed to the insulin receptor. Receptor binding properties of a series of A- and B-domain analogues were compared using rat L6 myoblasts, soluble
G K, Shooter, B, Magee, M A, Soos, G L, Francis, K, Siddle, J C, Wallace   +5 more
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Type 1 IGF receptor in human breast diseases

Breast Cancer Research and Treatment, 1992
The first step of the action of IGF1 and IGF2 (IGFs) is their binding to membrane receptors. IGF binding sites have been characterized by competitive binding and cross-linking techniques in human breast cancer cell lines as well as in human breast cancers and in human benign breast diseases.
J P, Peyrat, J, Bonneterre
openaire   +2 more sources

Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor

Regulatory Peptides, 1996
The hydrophobic residue Phe-23 lies on a surface of insulin like growth factor 1 (IGF-1) which may be involved in binding to the type I IGF and insulin receptors. The possibility that Phe-23 participates directly in binding to these receptors has been investigated by comparing the properties of [F23G]IGF-1, a mutant of insulin-like growth factor 1 in ...
D R, Hodgson, F E, May, B R, Westley
openaire   +2 more sources

IGF Resistance: The Role of the Type 1 IGF Receptor

2005
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is the dominant regulator of somatic growth in vertebrates. Growth deficits of varying severity follow experimental deletion of individual IGF axis components, with all but about 15% of the growth of an adult mouse explicable by the combined contributions of growth hormone and IGF-I ...
Steven D. Chernausek, M. Jennifer Abuzzahab, Wieland Kiess, Doreen Osgood, Anke Schneider, Robert J. Smith   +5 more
openaire   +1 more source

P46 Studies on the bivalent interaction of IGF-II with the insulin and type 1 IGF receptors

Growth Hormone & IGF Research, 2010
demonstrated the role of the IGF system in the regulation of trophoblast proliferation and survival and alterations in the IGF ligands or the receptors could have implications in the pathogenesis of trophoblastic diseases. The aim of this study was to investigate the role of the IGF system in trophoblast cell differentiation by evaluating the ...
C.L. Alvino, S.C. Ong, K.A. McNeil, G.W. Booker, J.C. Wallace, B.E. Forbes   +5 more
openaire   +1 more source

Developmental changes in the expression patterns of IGFs, type 1 IGF receptor and IGF-binding proteins-2 and -4 in perinatal rat lung

Journal of Molecular Endocrinology, 1995
ABSTRACT The insulin-like growth factors (IGF-I and IGF-II), their receptors and binding proteins (IGFBPs) are endogenously expressed in a number of tissues including the lung during fetal and neonatal development. This endogenous autocrine/paracrine IGF 'system', together with endocrine sources, contributes to the regulation of lung ...
D C, Batchelor, A M, Hutchins, M, Klempt, S J, Skinner   +3 more
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Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

Molecular and Cellular Endocrinology, 1998
The Type 1 IGF receptor plays a critical role in cell progression. During normal ontogeny it is expressed by every proliferating cell, where it functions as a potent cell survival agent. Disruption of the Type 1 IGF receptor gene by homologous recombination results in severely growth retarded animals which invariably die at birth.
openaire   +2 more sources