Results 251 to 260 of about 35,242,900 (287)

Insulin-like growth factor (IGF) suppression of IGFBP-1 production: evidence for mediation by the type I IGF receptor

Regulatory Peptides, 1993
The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells. Both IGF-I and IGF-II in concentrations as low as 1-10 nmol/l caused significant suppression of IGFBP-I protein levels.
P D, Lee, A, Suwanichkul, L A, DePaolis, M B, Snuggs, S L, Morris, D R, Powell   +5 more
openaire   +2 more sources

Influence of blockers for the estrogen receptor (ER) and type 1 IGF-receptor on the levels of ER, ER mRNA and IGF-I mRNA in the rat uterus

The Journal of Steroid Biochemistry and Molecular Biology, 1996
The effects on the uterine concentration of the estrogen receptor (ER), ER mRNA and IGF-I mRNA were monitored in ovariectomized (OVX) rats treated with blockers for the estrogen receptor (ER) (ICI 182780) or the type 1 IGF receptor (H-1356), alone or in combination with estradiol (E2).
L, Sahlin, H, Eriksson
openaire   +2 more sources

Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis.

European journal of biochemistry, 2002
Insulin-like growth factor (IGF) binding to the type 1 IGF receptor (IGF1R) elicits mitogenic effects, promotion of differentiation and protection from apoptosis. This study has systematically measured IGF1R binding affinities of IGF-I, IGF-II and 14 IGF analogues to a recombinant high-affinity form of the IGF1R using BIAcore technology.
Briony E, Forbes, Perry J, Hartfield, Kerrie A, McNeil, Kathy H, Surinya, Steven J, Milner, Leah J, Cosgrove, John C, Wallace   +6 more
openaire   +4 more sources

Molecular Biology of the Type 1 IGF Receptor

1999
The biological actions of the insulin-like growth factors (IGFs), as described in this book, are mediated by a family of cell-surface receptors that includes the insulin, the type 1, and the type 2 IGF receptors (1–6). Although there is a certain degree of cross-interaction between the various ligands and their receptors, current evidence supports the ...
openaire   +1 more source

Temporal and spatial expression of the four Igf ligands and two Igf type 1 receptors in zebrafish during early embryonic development

Gene Expression Patterns, 2014
The insulin-like growth factor (Igf) family is an evolutionarily conserved system essential for normal growth and development in vertebrates. Unlike mammals, four distinct Igf ligands (Igf1, Igf2a, Igf2b and Igf3) and two Igf type 1 receptors (Igf1ra and Igf1rb) are present in zebrafish. However, the localization of these multiple ligands and receptors
Jianzhen, Li, Peng, Wu, Yun, Liu, Deshou, Wang, Christopher H K, Cheng   +4 more
openaire   +2 more sources

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

Mechanisms of Ageing and Development, 1993
Insulin-like growth factor-1 (IGF-1) is an anabolic hormone that mediates the actions of growth hormone (GH) and is found at lower concentrations in aged animals. These decreases in GH and IGF-1 appear to have important physiological consequences for aging, since protein synthesis decreases with age, and administration of GH and/or IGF-1 has been shown
A P, D'Costa, J E, Lenham, R L, Ingram, W E, Sonntag   +3 more
openaire   +2 more sources

Significance of nuclear phospholipase C signaling through type 1 IGF receptor.

Journal of endocrinological investigation, 2004
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation.
COCCO, LUCIO ILDEBRANDO, S. Capitani, MARALDI, NADIR, MARTELLI, ALBERTO MARIA, MAZZOTTI, GIOVANNI, MANZOLI, FRANCESCO ANTONIO   +5 more
openaire   +5 more sources

Gene expression of insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation.

Endocrinology, 1992
Altered gene expression and/or actions of the insulin-like growth factors (IGFs) have been implicated in the mediation of both pre- and postnatal growth retardation secondary to glucocorticoid excess. To investigate this possibility, we assessed the gene expression of the IGFs, the type I IGF receptor, and IGF-binding proteins (IGFBPs) in 20-day ...
W A, Price, A D, Stiles, B M, Moats-Staats, A J, D'Ercole   +3 more
openaire   +3 more sources

Regulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles

Journal of Endocrinology, 1996
Abstract The relative abundance and location of type 1 IGF receptors in sheep muscles have been measured to determine whether changes occur during post-natal growth and nutritional stress. Using the technique of histological autoradiography, specific binding of 125I-IGF-I in muscle fibre and connective tissue of M.
J M, Oldham, J A, Martyn, S P, Kirk, J R, Napier, J J, Bass   +4 more
openaire   +2 more sources

Localization of Insulin and Type 1 IGF Receptors in Rat Brain by in Vitro Autoradiography and in Situ Hybridization

1991
Insulin and the insulin-like growth factors (IGFs) are structurally related, circulating hormones that regulate growth and intermediary metabolism in virtually all tissues. In many organs their function has been well defined but in the adult CNS no general understanding of their action and importance is available.
J L, Marks, M G, King, D G, Baskin
openaire   +2 more sources