Results 261 to 270 of about 35,242,900 (287)

Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation

Endocrine, 2009
Growth hormone (GH) and IGF-I have been implicated in the pathogenesis of type I diabetic (DM) nephropathy. We investigated renal GH receptor (GHR) and IGF-type 1 receptor (IGF1R) signaling in an animal model of type I DM. Kidney tissue was examined for GHR and IGF1R key signaling molecules.
Daniel, Landau, Renanah, Eshet, Ariel, Troib, Yotam, Gurman, Yu, Chen, Ralph, Rabkin, Yael, Segev   +6 more
openaire   +2 more sources

Detection of type 1 insulinlike growth factor (IGF) receptors in Wilms' tumors.

The American journal of pathology, 1988
Insulinlike growth factors (IGFs) are peptide hormones that regulate proliferation and differentiation of several types of normal and neoplastic cells. Recent studies of Wilms' tumor, a childhood kidney neoplasm, have detected increased expression of IGF-2 mRNA and protein.
T, Gansler, K D, Allen, C F, Burant, T, Inabnett, A, Scott, M G, Buse, D A, Sens, A J, Garvin   +7 more
openaire   +1 more source

Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity.

Endocrinology, 2001
Insulin-like growth factor binding proteins (IGFBPs) regulate the cellular actions of the IGFs owing to their strong affinities, which are equal to or stronger than the affinity of the type 1 IGF receptor (IGF-IR), the mediator of IGF signal transduction.
J M, Ricort, M, Binoux
openaire   +1 more source

Disorders of IGFs and IGF-1R signaling pathways

Molecular and Cellular Endocrinology, 2020
Jan M Wit, Briony Forbes
exaly  

Analysis of the interaction of IGF I and structural mutants of IGF I with the IGF types 1 and 2 and insulin receptors

1988
Margaret A. Cascieri, Gary G. Chicchi, Barbara G. Green, Joy Applebaum, Nancy S. Hayes, Marvin L. Bayne   +5 more
openaire   +1 more source

IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2003
Michael Mengel, Hans Kreipe, Juergen Klempnauer   +2 more
exaly  

Discovery of a gonad-specific IGF subtype in teleost

Biochemical and Biophysical Research Communications, 2008
Christopher H K Cheng, Wang D, Zhihao Liu   +2 more
exaly  

Gastric cancer: the role of insulin‐like growth factor 2 (IGF 2) and its receptors (IGF 1R and M6‐P/IGF 2R)

Journal of Pathology, 2003
Krešimir Pavelić
exaly  

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

Oncogene, 1999
Ira D Goldfine, Laura Sciacca, Riccardo Vigneri   +2 more
exaly  

Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients

Kidney International, 2005
Thomas Storer
exaly