Results 221 to 230 of about 89,239 (242)

IGF Resistance: The Role of the Type 1 IGF Receptor

2005
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is the dominant regulator of somatic growth in vertebrates. Growth deficits of varying severity follow experimental deletion of individual IGF axis components, with all but about 15% of the growth of an adult mouse explicable by the combined contributions of growth hormone and IGF-I ...
Steven D. Chernausek, M. Jennifer Abuzzahab, Wieland Kiess, Doreen Osgood, Anke Schneider, Robert J. Smith   +5 more
openaire   +1 more source

Developmental changes in the expression patterns of IGFs, type 1 IGF receptor and IGF-binding proteins-2 and -4 in perinatal rat lung

Journal of Molecular Endocrinology, 1995
ABSTRACT The insulin-like growth factors (IGF-I and IGF-II), their receptors and binding proteins (IGFBPs) are endogenously expressed in a number of tissues including the lung during fetal and neonatal development. This endogenous autocrine/paracrine IGF 'system', together with endocrine sources, contributes to the regulation of lung cell proliferation.
D C, Batchelor, A M, Hutchins, M, Klempt, S J, Skinner   +3 more
openaire   +2 more sources

Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

Molecular and Cellular Endocrinology, 1998
The Type 1 IGF receptor plays a critical role in cell progression. During normal ontogeny it is expressed by every proliferating cell, where it functions as a potent cell survival agent. Disruption of the Type 1 IGF receptor gene by homologous recombination results in severely growth retarded animals which invariably die at birth.
openaire   +2 more sources

Insulin-like growth factor (IGF) suppression of IGFBP-1 production: evidence for mediation by the type I IGF receptor

Regulatory Peptides, 1993
The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells. Both IGF-I and IGF-II in concentrations as low as 1-10 nmol/l caused significant suppression of IGFBP-I protein levels.
P D, Lee, A, Suwanichkul, L A, DePaolis, M B, Snuggs, S L, Morris, D R, Powell   +5 more
openaire   +2 more sources

Influence of blockers for the estrogen receptor (ER) and type 1 IGF-receptor on the levels of ER, ER mRNA and IGF-I mRNA in the rat uterus

The Journal of Steroid Biochemistry and Molecular Biology, 1996
The effects on the uterine concentration of the estrogen receptor (ER), ER mRNA and IGF-I mRNA were monitored in ovariectomized (OVX) rats treated with blockers for the estrogen receptor (ER) (ICI 182780) or the type 1 IGF receptor (H-1356), alone or in combination with estradiol (E2).
L, Sahlin, H, Eriksson
openaire   +2 more sources

Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis.

European journal of biochemistry, 2002
Insulin-like growth factor (IGF) binding to the type 1 IGF receptor (IGF1R) elicits mitogenic effects, promotion of differentiation and protection from apoptosis. This study has systematically measured IGF1R binding affinities of IGF-I, IGF-II and 14 IGF analogues to a recombinant high-affinity form of the IGF1R using BIAcore technology.
Briony E, Forbes, Perry J, Hartfield, Kerrie A, McNeil, Kathy H, Surinya, Steven J, Milner, Leah J, Cosgrove, John C, Wallace   +6 more
openaire   +4 more sources

Temporal and spatial expression of the four Igf ligands and two Igf type 1 receptors in zebrafish during early embryonic development

Gene Expression Patterns, 2014
The insulin-like growth factor (Igf) family is an evolutionarily conserved system essential for normal growth and development in vertebrates. Unlike mammals, four distinct Igf ligands (Igf1, Igf2a, Igf2b and Igf3) and two Igf type 1 receptors (Igf1ra and Igf1rb) are present in zebrafish. However, the localization of these multiple ligands and receptors
Jianzhen, Li, Peng, Wu, Yun, Liu, Deshou, Wang, Christopher H K, Cheng   +4 more
openaire   +2 more sources

Molecular Biology of the Type 1 IGF Receptor

1999
The biological actions of the insulin-like growth factors (IGFs), as described in this book, are mediated by a family of cell-surface receptors that includes the insulin, the type 1, and the type 2 IGF receptors (1–6). Although there is a certain degree of cross-interaction between the various ligands and their receptors, current evidence supports the ...
openaire   +1 more source

Significance of nuclear phospholipase C signaling through type 1 IGF receptor.

Journal of endocrinological investigation, 2004
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation.
COCCO, LUCIO ILDEBRANDO, S. Capitani, MARALDI, NADIR, MARTELLI, ALBERTO MARIA, MAZZOTTI, GIOVANNI, MANZOLI, FRANCESCO ANTONIO   +5 more
openaire   +5 more sources

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

Mechanisms of Ageing and Development, 1993
Insulin-like growth factor-1 (IGF-1) is an anabolic hormone that mediates the actions of growth hormone (GH) and is found at lower concentrations in aged animals. These decreases in GH and IGF-1 appear to have important physiological consequences for aging, since protein synthesis decreases with age, and administration of GH and/or IGF-1 has been shown
A P, D'Costa, J E, Lenham, R L, Ingram, W E, Sonntag   +3 more
openaire   +2 more sources