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Results 121 to 130 of about 71,317 (233)

Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Insulin‐like growth factor 1 receptor (IGF‐1R) is crucial for immunological control and the development of different types of cancer. It is still uncertain how the expression of IGF‐1R impacts hypopharyngeal squamous cell carcinoma (HPSCC) and whether it has any predictive value for prognosis.
Wen‐Jing Li +10 more
wiley +1 more source

IGFBP-2 and IGF-II: Key Components of the Neural Stem Cell Niche? Implications for Glioblastoma Pathogenesis. [PDF]

Int J Mol Sci
Harland AJ, Perks CM.
europepmc +1 more source

Alternate Day Fasting Enhances Intestinal Epithelial Function During Aging by Regulating Mitochondrial Metabolism

Aging Cell, EarlyView.
Alternate day fasting alleviates aging‐induced intestinal epithelial barrier damage by regulating mitochondrial metabolism in small intestinal stem cells. ABSTRACT With advancing age, the decline in intestinal stem cell (ISC) function can lead to a series of degenerative changes in the intestinal epithelium, a critical factor that increases the risk of
Heng Quan +12 more
wiley +1 more source

IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review). [PDF]

Oncol Lett
Zhang Y, Lv X.
europepmc +1 more source

Erratum to: ACP, volume 33, issues 1, 2, 3–4 and 5–6, 2010 [PDF]

Cellular Oncology, 2011
Brosens, R. P.M. +10 more
openaire +8 more sources

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, EarlyView.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang +22 more
wiley +1 more source

Brain-acting hepatokines: its impact on energy balance and metabolism. [PDF]

Front Neurosci
Giovanini L, Wanionok N, Perello M, Cornejo MP. +3 more
europepmc +1 more source

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice

Aging Cell, EarlyView.
Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary
S. J. M. Stefens +14 more
wiley +1 more source

Nanoparticle encapsulation enables systemic IGF-Trap delivery to inhibit intracerebral glioma growth. [PDF]

Neuro Oncol
Chen YM +13 more
europepmc +1 more source

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

Aging Cell, EarlyView.
Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan +176 more
wiley +1 more source

medicine
humans
insulin-like growth factor ii

insulin-like growth factor i
animals
receptor, igf type 1

3. good health
female
cell division