Results 131 to 140 of about 71,317 (233)

Secretion of placental peptide hormones: functions and trafficking. [PDF]

Front Endocrinol (Lausanne)
Ahmadi SM, Perez ML, Guardia CM.
europepmc   +1 more source

Cathepsin B Regulates Ovarian Reserve Quality and Quantity via Mitophagy by Modulating IGF1R Turnover

Aging Cell, EarlyView.
Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility,
Aradhana Mohanty, Anjali Kumari, Lava Kumar. S, Ajith Kumar, Pravin Birajdar, Rohit Beniwal, Mohd Athar, Kiran Kumar. P, H.B.D.Prasada Rao   +8 more
wiley   +1 more source

Insulin‑like growth factor in cancer: New perspectives (Review). [PDF]

Mol Med Rep
Wu D, Dong S, Zhou W.
europepmc   +1 more source

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog. [PDF]

J Vet Intern Med
Soler Arias EA, Rodas Elvir R, Daly AF, Kooistra HS.   +3 more
europepmc   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Factors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence? [PDF]

World J Radiol
Fernandez CJ, Lakshmi V, Kamrul-Hasan ABM, Pappachan JM.   +3 more
europepmc   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Aging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Sam Olechnowicz, Rory Bowden, Rachael Hayward, Gary Low, Roslyn Muirhead, Jennie Brand‐Miller, Mikael Fogeltholm, Anne Raben, Marco Demaria, Stephen J. Fuller, Luigi Fontana   +16 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

The Role and Diagnostic Potential of Insulin-like Growth Factor 1 in Diabetic Retinopathy and Diabetic Macular Edema. [PDF]

Int J Mol Sci
Malepati A, Grant MB.
europepmc   +1 more source