Results 141 to 150 of about 71,317 (233)

A Novel GH Deficient Rat Model Reveals Cross‐Species Insights Into Aging

Aging Cell, EarlyView.
Mouse studies show disrupted GH signaling reduces body size, increases longevity, and improves health. We developed a CRISPR/Cas9 GH‐deficient rat model to address inconsistent rat evidence. GH‐deficient rats mirrored these findings, showing reduced body weight, increased body fat, enhanced insulin sensitivity, and altered gut microbiomes.
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu, Aron M. Geurts, Steven N. Austad, Liou Y. Sun   +5 more
wiley   +1 more source

Molecular basis of autism spectrum disorders. [PDF]

Mol Biol Rep
Desai R, Reddy S, Truong M, Thankam FG.
europepmc   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

Aging Cell, EarlyView.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini, Giovanni Piccinini, Liliana Milani, Mariangela Iannello   +3 more
wiley   +1 more source

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity. [PDF]

Sci Rep
Ali A, Zhang ZD, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S.   +6 more
europepmc   +1 more source

Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring

Alcohol, Clinical and Experimental Research, EarlyView.
Adults with prenatal alcohol exposure (PAE) are at increased risk for metabolic, immune, and cardiovascular disease. Little is known about the contribution of PAE to cerebrovascular disease, specifically during middle age, a time when stroke incidence and severity typically increase.
Shameena Bake, Marisa R. Pinson, David A. Hurst, Brendan O'Reilly, Nadia Samiya, Rajesh C. Miranda, Farida Sohrabji   +6 more
wiley   +1 more source

Teprotumumab in the management of thyroid eye disease mechanistic insights and adverse reactions: a comprehensive review. [PDF]

Front Endocrinol (Lausanne)
Xu Z, Hu N, Chen Q, Zhou Y, Huang Y, Hu S, Jin H, Tang Y.   +7 more
europepmc   +1 more source

A comparative study on infant growth between assisted reproductive technology pregnancy and natural pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Although ART infants are associated with a higher incidence of SGA and other birth outcomes, ART infants exhibit a marked tendency for rapid growth during their first year of life. ART, male infants, later gestational age at birth, SGA, city living, younger perinatal age, taller perinatal height, and heavier pre‐pregnancy weight were all independent ...
Anni Chen, Dongyang Wang, Yuyu Zhang, Qianqian Dai, Weixia Yang, Zixiao Zhou, Xuan Shi, Ziyue Zhou, Zijun Ni, Xun Zhuang   +9 more
wiley   +1 more source

Impact of anti‐VEGF therapy versus laser therapy on mortality and treatment outcomes in retinopathy of prematurity: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinopathy of prematurity (ROP) is a major cause of childhood blindness, and selecting the optimal treatment between anti‐vascular endothelial growth factor (anti‐VEGF) and laser therapy is crucial. Understanding their impact on key outcomes, particularly mortality, is essential for informed clinical decision‐making.
Wei‐De Wang, Ya‐Hsin Yao, Chiao‐Hsin Lan, Shih‐Heng Hung, Ta‐Hsin Tsung, Yann‐Guang Chen, Da‐Wen Lu, Jiann‐Torng Chen, Ke‐Hung Chien, Shu‐I Pao, Wei‐Ting Yen   +10 more
wiley   +1 more source

Exercise-Mediated Skeletal Muscle-Derived IL-6 Regulates Bone Metabolism: A New Perspective on Muscle-Bone Crosstalk. [PDF]

Biomolecules
Zhu C, Ding X, Chen M, Feng J, Zou J, Zhang L.   +5 more
europepmc   +1 more source

Endocrine Abnormalities and Growth Pattern in Single Large‐Scale Mitochondrial DNA Deletion Syndromes

Acta Paediatrica, EarlyView.
ABSTRACT Aim To assess the prevalence of endocrine disorders and investigate growth patterns in single large‐scale mitochondrial DNA deletion syndromes (SLSMDs). Methods A retrospective study of all children with SLSMD who attended Sheba Medical Center, Israel, from February 2017 to September 2024.
Ayman Daka, Einat Lahav, Omer Bar Yosef, Yoav Bolkier, Yael Levy‐Shraga, Yair Anikster, Elad Jacoby, Noah Gruber   +7 more
wiley   +1 more source