Results 151 to 160 of about 3,230,451 (211)

Insulin Receptors in Brain

1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein, Jana Havrankova, Jana Havrankova, Jesse Roth   +3 more
openaire   +3 more sources

The Immunology of the Insulin Receptor

Immunological Communications, 1976
We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett, Jeffrey S. Flier, C. R. Kahn, Jesse Roth   +3 more
openaire   +3 more sources

Insulin Receptor and Insulin Action [PDF]

, 1990
Insulin generates a complex assay of biological responses in a variety of cell systems. The first step in insulin action is binding of the hormone to its specific cell surface receptor. This receptor is an oligomer consisting of two α-subunits with Mr 130 kDa, and twos-subunits with Mr 95 kDa; the different subunits are linked together by disulfide ...
E Van Obberghen, Robert Ballotti
openaire   +1 more source

Insulin resistance: Review of the underlying molecular mechanisms

Journal of Cellular Physiology, 2018
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi, F. R. Farrokhi, A. Butler, A. Sahebkar   +3 more
semanticscholar   +1 more source

Insulin Receptor Antibodies and Insulin Resistance

Southern Medical Journal, 1999
The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
Spencer J, Magsino Ch
openaire   +2 more sources

The Insulin Receptor Family

1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina, Richard A. Roth, Karen A. Seta   +2 more
openaire   +3 more sources

Insulin receptors and insulin signalling

1995
International ...
Taouis, Mohammed, Simon, J.
openaire   +3 more sources

Insulin Receptor Autoimmunity and Insulin Resistance

Journal of Pediatric Endocrinology and Metabolism, 2008
The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping Zhou, Maria G. Vogiatzi, Noel K. Maclaren, Svetlana Ten, Svetlana Ten, Sunil Sinha, Sunil Sinha, Neesha Ramchandani, Neesha Ramchandani   +8 more
openaire   +2 more sources

Mutations in the insulin receptor gene

Endocrine Reviews, 1992
I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI, CAMA, A, ACCILI, D, BARBETTI, F, QUON, MJ, SIERRA, MD, SUZUKI, Y, KOLLER, E, LEVYTOLEDANO, R, WERTHEIMER, E, MONCADA, VY, KADOWAKI, H, KADOWAKI, T   +12 more
openaire   +6 more sources

The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors

Endocrinology, 1977
Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of four insulin analogues ...
Barry H. Ginsberg, Jesse Roth, Ronald Kahn   +2 more
openaire   +3 more sources