Results 11 to 20 of about 3,230,451 (211)
Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor
Bio-Protocol, 2023 Far-western blotting, derived from the western blot, has been used to detect interactions between proteins in vitro, such as receptor–ligand interactions.
Jinghua Peng +3 more
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Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
The Journal of Headache and Pain, 2022 Background Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent ...
Judit Rosta +5 more
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ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES [PDF]
Biotechnologia Acta, 2014 The insulin receptor was isolated from the liver cell membranes of control and diabetic rats. The protein purity was controlled by electrophoresis and Western blot.
T. I. Halenova +3 more
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Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. [PDF]
PLoS ONE, 2013 We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet.
David J Pedersen +3 more
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Insulin and insulin receptors in rodent brain [PDF]
Diabetologia, 1981 While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding.
Jesse Roth +3 more
openaire +4 more sources
Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim +5 more
doaj +1 more source
The Journal of Pediatrics, 1981 Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
openaire +4 more sources
Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
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Molecular and Cellular Biology, 2019 Brain insulin resistance is a key pathological feature contributing to obesity, diabetes, and neurodegenerative disorders, including Alzheimer’s disease (AD).
Mario Fernández-de Frutos +9 more
semanticscholar +1 more source