Results 11 to 20 of about 378,083 (173)
Insulin receptor trafficking steers insulin action
Molecular Metabolism, 2016 In this issue, Boothe and colleagues analyze insulin receptor trafficking in pancreatic beta cells to unravel the trafficking route of insulin receptors and provide novel insights into the potentially different roles of insulin receptor splice variants [1].
Simone Hausmann, Siegfried Ussar
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Insulin and insulin receptors in rodent brain [PDF]
Diabetologia, 1981 While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding.
Jesse Roth +3 more
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The Journal of Pediatrics, 1981 Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
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Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease [PDF]
Endocrine Reviews, 2009 In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This exon may be skipped in a developmental and tissue-specific manner. The IR, therefore, occurs in two isoforms (exon 11 minus IR-A and exon 11 plus IR-B). The most relevant functional difference between these two isoforms is the high affinity of IR-A for IGF-II.
BELFIORE A +4 more
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Frontiers in Endocrinology, 2022 AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim +5 more
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Scientific Reports, 2022 Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison +6 more
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Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
Frontiers in Endocrinology, 2014 Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein +2 more
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Revisiting the IGF-1R as a breast cancer target
npj Precision Oncology, 2017 The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
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BMC Neuroscience, 2007 Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G +4 more
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Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in ...
Hongzhou Liu +5 more
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