Results 281 to 290 of about 681,804 (310)
Some of the next articles are maybe not open access.
Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
openaire +2 more sources
Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action
1981Publisher Summary Insulin exerts a wide spectrum of effects at the cellular level. These include effects at the membrane level, for example, the stimulation of glucose and amino acid uptake; effects on both membrane and cytoplasmic enzymes; and effects on protein synthesis, DNA synthesis, cell growth, and differentiation.
Len C. Harrison +11 more
openaire +3 more sources
Biochimie, 1985
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
openaire +3 more sources
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
openaire +3 more sources
Autoantibodies to insulin receptors
Molecular and Cellular Endocrinology, 1981In summary, these studies using antibodies to the insulin receptor have provided some new insights into the structure of the insulin receptor and the action of insulin itself. They suggest that most of insulin's actions are mediated through a common pathway and these can be initiated by interaction of ligands other than insulin with the insulin ...
C. Ronald Kahn, Emmanuel Van Obberghen
openaire +3 more sources
1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
openaire +3 more sources
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
openaire +3 more sources
The Immunology of the Insulin Receptor
Immunological Communications, 1976We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett +3 more
openaire +3 more sources
Insulin Receptor and Insulin Action [PDF]
, 1990 Insulin generates a complex assay of biological responses in a variety of cell systems. The first step in insulin action is binding of the hormone to its specific cell surface receptor. This receptor is an oligomer consisting of two α-subunits with Mr 130 kDa, and twos-subunits with Mr 95 kDa; the different subunits are linked together by disulfide ...
E Van Obberghen, Robert Ballotti
openaire +1 more source
Insulin receptors and insulin signalling
1995International ...
Taouis, Mohammed, Simon, J.
openaire +6 more sources
Insulin Receptor Antibodies and Insulin Resistance
Southern Medical Journal, 1999The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
Spencer J, Magsino Ch
openaire +2 more sources
1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina +2 more
openaire +3 more sources
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina +2 more
openaire +3 more sources