Results 261 to 270 of about 2,226,169 (303)

The Insulin Receptor Family

1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
K A, Seta, K S, Kovacina, R A, Roth
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Insulin receptor and ageing

Pathologie Biologie, 2003
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Tamas, Fulop, Anis, Larbi, Nadine, Douziech   +2 more
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Mutations in the insulin receptor gene

Endocrine Reviews, 1992
I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI, CAMA, A, ACCILI, D, BARBETTI, F, QUON, MJ, SIERRA, MD, SUZUKI, Y, KOLLER, E, LEVYTOLEDANO, R, WERTHEIMER, E, MONCADA, VY, KADOWAKI, H, KADOWAKI, T   +12 more
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The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors

Endocrinology, 1977
Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of four insulin analogues ...
B H, Ginsberg, C R, Kahn, J, Roth
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Insulin receptors and the site of action of insulin

Life Sciences, 1978
Abstract There is considerable evidence that insulin receptors located on the plasma membrane of target cells directly mediate the short- term effects of insulin on plasma membrane functions such as glucose transport. These receptors are composed of four subunits, contain two or more binding sites, and show features of negative cooperativity. Insulin
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Evolution of Insulin and Insulin Receptors

1987
Insulin traditionally has been considered to be a unique product of the vertebrate pancreas. More recent studies, however, have suggested that there may be extrapancreatic sources of insulin and that insulin may act on tissues other than its classic target tissues.
Derek LeRoith, William L. Lowe, Charles T. Roberts   +2 more
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Insulin Receptor and Insulin Action

1990
Insulin generates a complex assay of biological responses in a variety of cell systems. The first step in insulin action is binding of the hormone to its specific cell surface receptor. This receptor is an oligomer consisting of two α-subunits with Mr 130 kDa, and twos-subunits with Mr 95 kDa; the different subunits are linked together by disulfide ...
E. Obberghen, R. Ballotti
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Insulin Receptors

Annual Review of Pharmacology and Toxicology, 1983
S, Jacobs, P, Cuatrecasas
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Insulin Receptors

Annual Review of Medicine, 1973
B, Desbuquois, P, Cuatrecasas
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The Aetiology and Molecular Landscape of Insulin Resistance

Nature Reviews Molecular Cell Biology, 2021
David James, Morris J. Birnbaum, Jacqueline Stöckli   +2 more
exaly