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[Insulin and insulin receptor disorders].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993 openaire +1 more source
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Insulin, insulin receptors, and cancer
Journal of Endocrinological Investigation, 2016Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R +2 more
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Ketoacids and the insulin receptor
Diabetes, 1978The binding of insulin to a specific receptor on IM-9-cultured human lymphocytes was studied in vitro under conditions simulating diabetic ketoacidosis. Compared with control incubations at pH 7.4, binding was reduced by 19 per cent at pH 7.1 and by 48 per cent at pH 6.8. Addition of β-hydroxybutyrate, at concentrations similar to those seen clinically,
R I, Misbin +3 more
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Effect of insulin receptor autophosphorylation on insulin receptor binding
Molecular and Cellular Endocrinology, 1986Insulin receptor beta-subunit autophosphorylation, the first event occurring after insulin binding, plays a crucial role in modulation of receptor-associated kinase activity towards exogenous substrates and possibly in the transmission of biological signals of insulin. Receptor autophosphorylation strongly depends on insulin receptor occupancy.
Gherzi R +3 more
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The insulin receptor endocytosis
2023Insulin signaling controls multiple aspects of animal physiology. At the cell surface, insulin binds and activates the insulin receptor (IR), a receptor tyrosine kinase. Insulin promotes a large conformational change of IR and stabilizes the active conformation.
Jiayi, Wu +2 more
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Diabetes, 1972
Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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THE ERYTHROCYTE INSULIN RECEPTOR
Australian Journal of Experimental Biology and Medical Science, 1981SummaryA precise, reproducible radioreceptor assay has been developed for insulin receptors on human erythrocytes. The mean specific binding in 11 normal volunteers was 7.7% ± 1.6 (S.D.) per 2.25 × 109 erythrocytes. The intra and inter assay coefficients of variation are 4%.
A, McElduff, C J, Eastman
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