Results 221 to 230 of about 463,867 (267)
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Autoantibodies to insulin receptors
Molecular and Cellular Endocrinology, 1981In summary, these studies using antibodies to the insulin receptor have provided some new insights into the structure of the insulin receptor and the action of insulin itself. They suggest that most of insulin's actions are mediated through a common pathway and these can be initiated by interaction of ligands other than insulin with the insulin ...
E, Van Obberghen, C R, Kahn
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Biochimie, 1985
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
E, Van Obberghen +8 more
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The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
E, Van Obberghen +8 more
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1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
J, Havrankova, J, Roth, M J, Brownstein
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Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
J, Havrankova, J, Roth, M J, Brownstein
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Insulin Receptor Autoimmunity and Insulin Resistance
Journal of Pediatric Endocrinology and Metabolism, 2008The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping, Zhou +5 more
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1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
K A, Seta, K S, Kovacina, R A, Roth
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The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
K A, Seta, K S, Kovacina, R A, Roth
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Pathologie Biologie, 2003
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Tamas, Fulop +2 more
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The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Tamas, Fulop +2 more
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Mutations in the insulin receptor gene
Endocrine Reviews, 1992I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI +12 more
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The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors
Endocrinology, 1977Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of four insulin analogues ...
B H, Ginsberg, C R, Kahn, J, Roth
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Insulin receptors and the site of action of insulin
Life Sciences, 1978Abstract There is considerable evidence that insulin receptors located on the plasma membrane of target cells directly mediate the short- term effects of insulin on plasma membrane functions such as glucose transport. These receptors are composed of four subunits, contain two or more binding sites, and show features of negative cooperativity. Insulin
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Annual Review of Pharmacology and Toxicology, 1983
S, Jacobs, P, Cuatrecasas
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S, Jacobs, P, Cuatrecasas
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