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[Insulin and insulin receptor disorders].

open access: yesNihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993
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Insulin, insulin receptors, and cancer

Journal of Endocrinological Investigation, 2016
Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R   +2 more
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Ketoacids and the insulin receptor

Diabetes, 1978
The binding of insulin to a specific receptor on IM-9-cultured human lymphocytes was studied in vitro under conditions simulating diabetic ketoacidosis. Compared with control incubations at pH 7.4, binding was reduced by 19 per cent at pH 7.1 and by 48 per cent at pH 6.8. Addition of β-hydroxybutyrate, at concentrations similar to those seen clinically,
R I, Misbin   +3 more
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