Results 251 to 260 of about 2,226,169 (303)

Insulin Receptor Antibodies and Insulin Resistance

Southern Medical Journal, 1999
The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
C H, Magsino, J, Spencer
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Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease [PDF]

Endocrine Reviews, 2009
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This exon may be skipped in a developmental and tissue-specific manner. The IR, therefore, occurs in two isoforms (exon 11 minus IR-A and exon 11 plus IR-B). The most relevant functional difference between these two isoforms is the high affinity of IR-A for IGF-II.
Laura Sciacca, Riccardo Vigneri, Francesco Frasca   +2 more
exaly   +5 more sources

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

1981
Publisher Summary Insulin exerts a wide spectrum of effects at the cellular level. These include effects at the membrane level, for example, the stimulation of glucose and amino acid uptake; effects on both membrane and cytoplasmic enzymes; and effects on protein synthesis, DNA synthesis, cell growth, and differentiation.
C R, Kahn, K L, Baird, J S, Flier, C, Grunfeld, J T, Harmon, L C, Harrison, F A, Karlsson, M, Kasuga, G L, King, U C, Lang, J M, Podskalny, E, Van Obberghen   +11 more
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The Immunology of the Insulin Receptor

Immunological Communications, 1976
We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
J S, Flier, C R, Kahn, D B, Jarrett, J, Roth   +3 more
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Insulin Receptors and Insulin Resistance

Annual Review of Medicine, 1983
Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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The insulin receptor and the kidney

Current Opinion in Nephrology and Hypertension, 2013
In recent years, it has become clear that the insulin receptor is important in a variety of renal cell types. It is through this transmembrane receptor that insulin, and to a lesser extent insulin-like growth factor, hormones bind and can control important cellular functions.
Hale, Lorna J, Coward, Richard J M
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Autoantibodies to insulin receptors

Molecular and Cellular Endocrinology, 1981
In summary, these studies using antibodies to the insulin receptor have provided some new insights into the structure of the insulin receptor and the action of insulin itself. They suggest that most of insulin's actions are mediated through a common pathway and these can be initiated by interaction of ligands other than insulin with the insulin ...
E, Van Obberghen, C R, Kahn
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The insulin receptor kinase

Biochimie, 1985
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
E, Van Obberghen, R, Ballotti, H, Gazzano, M, Fehlmann, B, Rossi, S, Gammeltoft, A, Debant, Y, Le Marchand-Brustel, A, Kowalski   +8 more
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Insulin Receptor Autoimmunity and Insulin Resistance

Journal of Pediatric Endocrinology and Metabolism, 2008
The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping, Zhou, Svetlana, Ten, Sunil, Sinha, Neesha, Ramchandani, Maria, Vogiatzi, Noel, Maclaren   +5 more
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Insulin Receptors in Brain

1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
J, Havrankova, J, Roth, M J, Brownstein
openaire   +2 more sources