Results 21 to 30 of about 3,230,451 (211)

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 Receptor-insulin receptor substrate and STAT3 signaling

Oncogene, 2015
The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion.
E. Sanchez-Lopez, E. Flashner-Abramson, S. Shalapour, Zhenyu Zhong, K. Taniguchi, A. Levitzki, M. Karin   +6 more
semanticscholar   +1 more source

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro

Frontiers in Endocrinology, 2014
Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein, Patrick F. Dillon, Abigail ePodufaly   +2 more
doaj   +1 more source

Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand

Scientific Reports, 2022
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison, Laura Wood, Karen J. Edler, James Doutch, Gareth J. Price, Francoise Koumanov, Paul Whitley   +6 more
doaj   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons

BMC Neuroscience, 2007
Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G, Persiyantseva Nadezhda A, Senilova Yana E, Storozhevykh Tatiana P, Pomytkin Igor A   +4 more
doaj   +1 more source

Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats

Evidence-Based Complementary and Alternative Medicine, 2011
β-Endorphin plays a major role in the amelioration of insulin resistance. The present study documents that myricetin (3,5,7,3′, 4′, 5′-hexahydroxyflavone) ameliorates insulin resistance by enhancing β-endorphin production in insulin-resistant rats.
T. Tzeng, S. Liou, I. Liu
semanticscholar   +1 more source

Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in ...
Hongzhou Liu, Nan Li, Mengmeng Jin, Xinyu Miao, Xinjie Zhang, Wenwen Zhong   +5 more
doaj   +1 more source

Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond

Frontiers in Endocrinology, 2022
The mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. Significant advances have been gained from recent structural studies in understanding how insulin binds to its receptor.
Shee Chee Ong, Alessia Belgi, Allanah L. Merriman, Carlie A. Delaine, Bianca van Lierop, Sofianos Andrikopoulos, Andrea J. Robinson, Briony E. Forbes   +7 more
doaj   +1 more source

A novel nonsense mutation in the insulin receptor gene in a patient with HAIR-AN syndrome and endometrial cancer

Molecular Genetics and Metabolism Reports, 2023
Severe insulin resistance can be caused by rare genetic defects in the insulin receptor known as insulin receptoropathies. These genetic defects cause a wide spectrum of clinical manifestations ranging from mild syndromes to lethal disorders. Among those
Dalia Cuenca, Jose Luis Ventura-Gallegos, Paloma Almeda-Valdes, María Teresa Tusié-Luna, Alfredo Reza-Albarran, Laura Ventura-Ayala, Ma. Luisa Ordoñez-Sánchez, Yayoi Segura-Kato, Francisco Javier Gomez-Perez, Michelle De Puy Conte, Lizbet Ruilova Gonzalez, Alejandro Zentella-Dehesa   +11 more
doaj   +1 more source

Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Nature Communications, 2022
DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of ...
Junhong Kim, Na-Oh Yunn, Mangeun Park, Jihan Kim, Seongeun Park, Yoojoong Kim, Jeongeun Noh, Sung Ho Ryu, Yunje Cho   +8 more
doaj   +1 more source