Results 11 to 20 of about 2,226,169 (303)

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro [PDF]

Frontiers in Endocrinology, 2014
Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein, Patrick F. Dillon, Abigail ePodufaly   +2 more
doaj   +2 more sources

Insulin Analogues for Insulin Receptor Studies and Medical Applications [PDF]

, 2012
The structure of insulin molecule was determined by Dorothy Hodgkin in 1969. Subsequently, it has been established that insulin must rearrange upon binding to its receptor (Insulin Receptor – IR).
Watson, Christopher John
core   +6 more sources

Insulin-mediated modulation of NMDA receptor currents in Xenopus oocytes.

, 2005
Insulin-mediated modulation of NMDA receptor currents in Xenopus ...
Michelle L. Jones (7986683)
core   +5 more sources

The insulin receptor [PDF]

The Journal of Pediatrics, 1981
Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
openaire   +3 more sources

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand

Scientific Reports, 2022
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison, Laura Wood, Karen J. Edler, James Doutch, Gareth J. Price, Francoise Koumanov, Paul Whitley   +6 more
doaj   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
core   +1 more source

Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons

BMC Neuroscience, 2007
Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G, Persiyantseva Nadezhda A, Senilova Yana E, Storozhevykh Tatiana P, Pomytkin Igor A   +4 more
doaj   +1 more source

The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on [PDF]

, 2008
In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma
Hills, Claire E., Hodgkin, M. N., Squires, Paul E.   +2 more
core   +1 more source