Results 181 to 190 of about 6,476 (207)

MT1 Melatonin Receptor Reconstitution in Nanodiscs

2022
A way to study G protein-coupled receptors in a minimal system is to reconstruct artificial membrane mimics, made of detergent and/or of lipids in which the purified receptor is maintained. In particular, it is now possible to generate lipid nanoparticles, such as nanodiscs, in which a single receptor molecule is included.
Jean A, Boutin, Christel, Logez, Marjorie, Damian, Renaud, Wagner, Jean-Louis, Banères, Gilles, Ferry   +5 more
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Functionality of Melatonin Receptors: Recruitment of β-Arrestin at MT1

2022
The main process of downregulation of G protein-coupled receptors is desensitization by which the receptor is extruded from the plasma membrane and directed to the endosomal compartment for recycling. Typically, the first step of this phenomenon consists in the recruitment of the protein β-arrestin induced by the agonist.
Clémence, Dupré, Céline, Legros, Jean A, Boutin   +2 more
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Characterization of an Antibody to the Human Melatonin mt1 Receptor

Journal of Neuroendocrinology, 2001
AbstractMelatonin acts via high affinity, G‐protein coupled, seven transmembrane domain receptors. To precisely localize these receptors, antibodies were raised in chickens against a 15 amino acid fragment at the intracellular C‐terminal region of the human melatonin receptor subtype mt1 (DSSNDVADRVKWKPS, mt1338−352).
L M, Williams, J E, Drew, N W, Bunnett, E, Grady, P, Barrett, D R, Abramovich, A, Morris, D, Slater   +7 more
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Involvement of the mt1 melatonin receptor in human breast cancer

Cancer Letters, 2002
Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist,
P T, Ram, J, Dai, L, Yuan, C, Dong, T L, Kiefer, L, Lai, S M, Hill   +6 more
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Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease

Neuroscience Letters, 2001
The pineal hormone melatonin has two major functions: as a transducer of the circadian day-night signal across the seasons, and as a vasoactive substance regulating cerebral circulation. The vasoconstrictive effects of melatonin have been postulated to be mediated by the melatonin 1a-receptor (MT1).
E, Savaskan, G, Olivieri, L, Brydon, R, Jockers, K, Kräuchi, A, Wirz-Justice, F, Müller-Spahn   +6 more
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Expression of mt1 melatonin receptor in rat retina: evidence for multiple cell targets for melatonin

Neuroscience, 1999
Melatonin is synthesized in the retina at night and acts as a local modulator within this tissue by mediating the effects of darkness. We investigated the expression and localization of the mt1 (Mel1a) melatonin receptor in rat retina in order to disclose the cellular and molecular bases of melatonin's action in the mammalian retina.
H, Fujieda, S A, Hamadanizadeh, E, Wankiewicz, S F, Pang, G M, Brown   +4 more
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A new melatonin receptor ligand with mt1‐agonist and MT2‐antagonist properties

Journal of Pineal Research, 2000
It has been difficult, so far, to obtain melatonin analogs possessing high selectivity for the respective melatonin receptors, mt1 and MT2. In the present work, we report the synthesis and pharmacological characterization of a new compound N‐{2‐[5‐(2‐hydroxyethoxy)‐1H‐indol‐3‐yl)] ethyl} acetamide or 5‐hydroxyethoxy‐N‐acetyltryptamine (5‐HEAT).
NONNO R, LUCINI V, SPADONI, GILBERTO, PANNACCI M, CROCE A, ESPOSTI D, BALSAMINI, CESARINO, TARZIA, GIORGIO, FRASCHINI F, STANKOV BM   +9 more
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Nonradioactive In Situ Hybridization of MT1 Melatonin Receptor for the Identification of Melatonin Target Cells

2022
Identifying and phenotyping the target cells of a neuroendocrine messenger is one of the key steps to understand neuroendocrine networks and the physiological action of such messengers. In the absence of reliable antibodies directed against the receptor of a neuroendocrine messenger, detecting the expression of the messenger RNA of this receptor is an ...
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Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors

Biochemical Pharmacology, 2008
In order to interpret the effects of melatonin ligands in rats, we need to determine their activity at the receptor subtype level in the corresponding species. Thus, the rat melatonin rMT(1) receptor was cloned using DNA fragments for exon 1 and 2 amplified from rat genomic DNA followed by screening of a rat genomic library for the full length exon ...
Valérie, Audinot, Anne, Bonnaud, Line, Grandcolas, Marianne, Rodriguez, Nadine, Nagel, Jean-Pierre, Galizzi, Ales, Balik, Sophie, Messager, David G, Hazlerigg, Perry, Barrett, Philippe, Delagrange, Jean A, Boutin   +11 more
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