Results 191 to 200 of about 6,476 (207)

Functional MT1 and MT2 melatonin receptors in mammals.

Endocrine, 2005
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 G protein-coupled receptors viewed as potential targets for drug discovery.
Margarita L, Dubocovich, Magdalena, Markowska   +1 more
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Molecular Modeling of Human MT1 and MT2 Melatonin Receptors

2006
Malfunction of G-protein coupled receptors (GPCR) provokes large amount of diseases. Their adequate treatment requires rational design of new high affinity and high selectivity drugs targeting these receptors. Molecular modeling represents a powerful tool to solve the problem.
A. Chugunov, P. Chavatte, R. Efremov
openaire   +1 more source

Molecular pharmacology of the mouse melatonin receptors MT1 and MT2

European Journal of Pharmacology, 2012
The main melatonin receptors are two G-protein coupled receptors named MT(1) and MT(2). Having described the molecular pharmacology of the human versions of these receptors, we turned to two of the three species most useful in studying melatonin physiology: rat and sheep (a diurnal species used to understand the relationship between circadian rhythm ...
Devavry, Séverine, Legros, Celine, Brasseur, Chantal, Cohen, William, Guénin, Sophie-Pénélope, Delagrange, Philippe, Malpaux, Benoit, Ouvry, Christine, Cogé, Francis, Nosjean, Olivier, Boutin, Jany   +10 more
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Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors

Biochemical Pharmacology, 2004
The variations of the pharmacological properties of melatonin receptors between different mammalian species in transfected cell lines have been poorly investigated. In the present study, melatonin analogues have been used to characterize the pharmacology of the recombinant ovine melatonin receptor (oMT1) expressed in CHO cell lines and the native oMT1 ...
Mailliet, F., Audinot, V., Malpaux, Benoit, Bonnaud, Anthony, Delagrange, P., Migaud, Martine, Barrett, P., Viaud-Massuard, M.C., Lesieur, D., Lefoulon, F., Renard, P., Boutin, Jany   +11 more
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Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection.

Journal of pineal research, 2011
Recent studies have demonstrated that the human placenta is a novel source of adult stem cells. We have provided laboratory evidence that transplantation of these human placenta-derived cells in vitro and in vivo stroke models promotes functional recovery.
Kaneko, Yuji, Hayashi, Takuro, Yu, Seongjin, Tajiri, Naoki, Bae, Eunkyung C, Solomita, Marianna A, Chheda, Sonia H, Weinbren, Nathan L, Parolini, Ornella, Borlongan, Cesar V.   +9 more
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The melatonin-MT1 receptor axis modulates tumor growth in PTEN-mutated gliomas

Biochemical and Biophysical Research Communications, 2018
More than 40% of glioma patients have tumors that harbor PTEN (phosphatase and tensin homologue deleted on chromosome ten) mutations; this disease is associated with poor therapeutic resistance and outcome. Such mutations are linked to increased cell survival and growth, decreased apoptosis, and drug resistance; thus, new therapeutic strategies ...
Huihui Ma, Zhen Wang, Lei Hu, Shangrong Zhang, Chenggang Zhao, Haoran Yang, Hongzhi Wang, Zhiyou Fang, Lijun Wu, Xueran Chen   +9 more
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Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure

Life Sciences, 2001
In this study, we have demonstrated that 2-[125I]-iodomelatonin binds specifically to rat ovarian granulosa cell (GC) membranes with high affinity (KD=83 pM; Bmax=3.28 fmol/mg protein). Using immunoblot analysis and an anti-mt1 melatonin receptor antibody, we have also detected mt1 melatonin receptors in rat ovary.
J W, Clemens, M J, Jarzynka, P A, Witt-Enderby   +2 more
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Important amino acids for the function of the human MT1 melatonin receptor

Biochemical Pharmacology, 2003
Models of G protein-coupled melatonin receptor structure suggest that ligand recognition occurs in a binding pocket formed by transmembrane helices III, V and VII. Constitutively active mutations in G protein-coupled receptors have revealed that transmembrane helix III/intracellular loop 2 interface and transmembrane domain VI are critical regions in ...
Tarja, Kokkola, Steven M, Foord, Marie-Ange, Watson, Olli, Vakkuri, Jarmo T, Laitinen   +4 more
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Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in endometrial cancer cell line

Journal of Obstetrics and Gynaecology Research, 2008
AbstractAim: To determine the receptor subtypes of melatonin in estrogen receptor‐positive endometrial cancer cell line, Ishikawa, and the influence of melatonin on chemosensitivity.Methods: To confirm the subtype of melatonin on Ishikawa cells, cells were treated with melatonin alone and with antagonists against melatonin receptor luzindole and 4 ...
Mari, Watanabe, Yoichi, Kobayashi, Noriyuki, Takahashi, Kazushige, Kiguchi, Bunpei, Ishizuka   +4 more
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Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development

Zygote, 2010
SummaryIt is well known that melatonin provokes reproductive alterations in response to changes in hours of daylight in seasonally breeding mammals, exerting a regulatory role at different levels of the hypothalamic–pituitary–gonadal axis. Although it has also been demonstrated that melatonin may affect testicular activity in vertebrates, until now ...
IZZO G., ANIELLO F., FERRARA D., CAMPITIELLO M. R., SERINO, Ismene, MINUCCI, Sergio, D'ISTRIA M.   +6 more
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