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ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.
Ho VR, Goss GG, Leys SP.
europepmc +1 more source
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease. [PDF]
Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions responsible for memory and learning. It plays a key role in modulating rapid changes in synaptic transmission and plasticity.
Khaled S. Abd-Elrahman+1 more
semanticscholar +3 more sources
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Involvement of metabotropic glutamate 5 receptor in visceral pain
Pain, 2008Metabotropic glutamate 5 receptor (mGluR5) antagonists are effective in animal models of inflammatory and neuropathic pain. The involvement of mGluR5 in visceral pain pathways from the gastrointestinal tract is as yet unknown. We evaluated effects of mGluR5 antagonists on the colorectal distension (CRD)-evoked visceromotor (VMR) and cardiovascular ...
E. Lindström+10 more
semanticscholar +5 more sources
Metabotropic glutamate receptors, 5 years on
Neuropharmacology, 2017[no abstract]
Collingridge, Graham L.+3 more
openaire +4 more sources
The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders
2023The role of glutamate system in the etiology and pathophysiology of psychiatric disorders has gained considerable attention in the past two decades, including dysregulation of the metabotropic glutamatergic receptor subtype 5 (mGlu5). Thus, mGlu5 may represent a promising therapeutic target for psychiatric conditions, particularly stress-related ...
Ruth H, Asch+3 more
openaire +2 more sources
European Journal of Pharmacology, 2010
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the metabotropic glutamate receptor 5 (mGlu(5) receptor) and the NMDA-receptor in neurons. In rat hippocampal slices, it was shown that activation of mGlu(5) receptor by a positive modulator in the ...
Marc Grundl+7 more
openaire +3 more sources
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the metabotropic glutamate receptor 5 (mGlu(5) receptor) and the NMDA-receptor in neurons. In rat hippocampal slices, it was shown that activation of mGlu(5) receptor by a positive modulator in the ...
Marc Grundl+7 more
openaire +3 more sources