Results 181 to 190 of about 49,550 (244)

Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease. [PDF]

open access: possibleAnnual Review of Pharmacology and Toxicology, 2021
Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions responsible for memory and learning. It plays a key role in modulating rapid changes in synaptic transmission and plasticity.
Khaled S. Abd-Elrahman   +1 more
semanticscholar   +3 more sources

Involvement of metabotropic glutamate 5 receptor in visceral pain

Pain, 2008
Metabotropic glutamate 5 receptor (mGluR5) antagonists are effective in animal models of inflammatory and neuropathic pain. The involvement of mGluR5 in visceral pain pathways from the gastrointestinal tract is as yet unknown. We evaluated effects of mGluR5 antagonists on the colorectal distension (CRD)-evoked visceromotor (VMR) and cardiovascular ...
E. Lindström   +10 more
semanticscholar   +5 more sources

Metabotropic glutamate receptors, 5 years on

Neuropharmacology, 2017
[no abstract]
Collingridge, Graham L.   +3 more
openaire   +4 more sources

The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders

2023
The role of glutamate system in the etiology and pathophysiology of psychiatric disorders has gained considerable attention in the past two decades, including dysregulation of the metabotropic glutamatergic receptor subtype 5 (mGlu5). Thus, mGlu5 may represent a promising therapeutic target for psychiatric conditions, particularly stress-related ...
Ruth H, Asch   +3 more
openaire   +2 more sources

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology, 2010
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the metabotropic glutamate receptor 5 (mGlu(5) receptor) and the NMDA-receptor in neurons. In rat hippocampal slices, it was shown that activation of mGlu(5) receptor by a positive modulator in the ...
Marc Grundl   +7 more
openaire   +3 more sources

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