Results 11 to 20 of about 54,795 (218)

Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]

Annals of Clinical and Translational Neurology, 2016
Introduction Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung, Simon Akerman, Mark Wakefield, Charlotte Keywood, Peter J. Goadsby   +4 more
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Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]

Biological Research, 2017
Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze   +4 more
doaj   +3 more sources

Metabotropic glutamate receptor 5 in bulimia nervosa [PDF]

Scientific Reports, 2020
AbstractBulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 ...
Mihov, Yoan, Treyer, Valerie, Akkus, Funda, Toman, Erika, Milos, Gabriella, Ametamey, Simon M, Johayem, Anass, Hasler, Gregor   +7 more
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Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]

Schizophrenia Research, 2017
The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
Akkus, Funda, Treyer, Valerie, Ametamey, Simon M, Johayem, Anass, Buck, Alfred, Hasler, Gregor   +5 more
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Allosteric activation of metabotropic glutamate receptor 5 [PDF]

Journal of Biomolecular Structure and Dynamics, 2019
Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs. Ligands binding to this ancestral site of mGluR5 can act as positive (PAM), negative (NAM) or silent ...
Balázs Jójárt, Zoltán Orgován, Árpád Márki, Gáspár Pándy-Szekeres, György G. Ferenczy, György M. Keserű   +5 more
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Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer [PDF]

Journal of Biological Chemistry, 1996
The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with other members of the G protein-coupled receptor family and exhibit several distinctive features, including a large N-terminal extracellular domain with 17 cysteines in conserved positions.
C, Romano, W L, Yang, K L, O'Malley
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Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]

Molecular Pharmacology, 2016
The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Pratyush S, Suryavanshi, Subhash C, Gupta, Roopali, Yadav, Varun, Kesherwani, Jinxu, Liu, Shashank M, Dravid   +5 more
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mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
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Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]

PLoS ONE, 2013
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S Mahajan   +5 more
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Metabotropic glutamate receptor 5 in conditioned taste aversion learning [PDF]

Neurobiology of Learning and Memory, 2009
In conditioned taste aversion (CTA), animals learn to avoid a flavored solution (conditioned stimulus, CS) previously paired with internal malaise (unconditioned stimulus, US). Metabotropic glutamate receptor 5 (mGlu5) has been implicated in learning and memory processes and is necessary for CTA.
A, Simonyi, P, Serfozo, K E, Parker, A K, Ramsey, T R, Schachtman   +4 more
openaire   +2 more sources