Results 11 to 20 of about 476,675 (312)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]

Molecular Pain, 2012
Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W, Stemler Kristina M, Song David G, Abbosh Philip, Vogt Sherri K, Qiu Chang-Shen, Lai H Henry, Mysorekar Indira U, Gereau IV Robert W   +8 more
doaj   +4 more sources

Allosteric activation of metabotropic glutamate receptor 5 [PDF]

Journal of Biomolecular Structure and Dynamics, 2019
Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs. Ligands binding to this ancestral site of mGluR5 can act as positive (PAM), negative (NAM) or silent ...
Balázs Jójárt, Zoltán Orgován, Árpád Márki, Gáspár Pándy-Szekeres, György G. Ferenczy, György M. Keserű   +5 more
openaire   +7 more sources

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety [PDF]

Frontiers in Molecular Neuroscience, 2019
Amongst the many neurotransmitter systems causally linked to the expression of social behavior, glutamate appears to play a pivotal role. In particular, metabotropic glutamate 5 (mGlu5) receptors have received much attention as its altered function has ...
Arnau Ramos-Prats, Julia Kölldorfer, E. Paolo, Maximilian Zeidler, G. Schmid, F. Ferraguti   +5 more
semanticscholar   +6 more sources

Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]

Biological Research, 2017
Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze   +4 more
doaj   +4 more sources

Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome [PDF]

Brain Sciences, 2020
Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5) in fmr1 knockout (KO) mouse ...
James R. Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Anil Mathur, Keith Slifer, Thomas Sedlak, Samuel D. Martin, Zabecca Brinson, Pankhuri Vyas, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic   +14 more
doaj   +3 more sources

Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]

Brain Sciences, 2019
Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten, Eleanor B. Holmgren, Tiffany A. Wills   +2 more
doaj   +4 more sources

Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors. [PDF]

British Journal of Anaesthesia, 2006
BACKGROUND Group I metabotropic glutamate receptors (mGluRs) have been reported to regulate N-methyl-d-aspartate (NMDA) receptor function in various brain regions.
J-H Sou, M. Chan, Hh Chen
semanticscholar   +3 more sources

Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice. [PDF]

The International Journal of Neuropsychopharmacology, 2008
The metabotropic glutamate receptor 5 (mGlu5) has been implicated in ethanol- and drug-seeking behaviours in rodent studies. Here we examine a number of ethanol-related behavioural assays in mice lacking mGlu5 and wild-type littermates.
Michael K. Bird, J. Kirchhoff, E. Djouma, A. Lawrence   +3 more
semanticscholar   +4 more sources

Metabotropic glutamate receptor 5 in bulimia nervosa [PDF]

Scientific Reports, 2020
AbstractBulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 ...
Yoan Mihov, Yoan Mihov, Anass Johayem, Gregor Hasler, Gregor Hasler, Funda Akkus, Erika Toman, Valerie Treyer, Gabriella Milos, Simon M. Ametamey   +9 more
openaire   +5 more sources

The role of the metabotropic glutamate receptor 5 in nicotine addiction [PDF]

CNS Spectrums, 2020
AbstractThis review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has ...
Sylvia Terbeck, Gregor Hasler, Valerie Treyer, Janan Dietrich, Funda Akkus, Funda Akkus, Stefanie Hornschuh, Connor J. Haggarty   +7 more
openaire   +3 more sources