Results 191 to 200 of about 54,795 (218)

Anxiolytic Effects of Natural Products: Pathological Mechanisms, Molecular Targets, Therapeutic Prospects. [PDF]

Neuropsychiatr Dis Treat
Yu X, Li G, Liu J, Chen Y, Wang F.
europepmc   +1 more source

Differing Patterns of Ionotropic Glutamate Receptor Subunit Gene Expression in Paraventricular Hypothalamic Nucleus Subregions following Angiotensin II Hypertension in Male Mice and Female Mice with Advanced Ovarian Failure.

Neuroendocrinology
Sommer G, Hussein SO, Milner TA, Glass MJ.   +3 more
europepmc   +1 more source

Metabotropic glutamate receptor type 5 effects on ALS progression

, 2018
Tiziana Bonifacino, Marco Milanese, Marcello Melone, Francesca Provenzano, Aldamaria Puliti, Cesare Usai, Giambattista Bonanno   +6 more
openaire   +1 more source

Biased allosteric modulators at the metabotropic glutamate receptor 5

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Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease

Annual Review of Pharmacology and Toxicology, 2022
Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions responsible for memory and learning. It plays a key role in modulating rapid changes in synaptic transmission and plasticity. mGluR5 supports long-term changes in synaptic strength by regulating the transcription and translation of essential synaptic proteins.
Khaled S, Abd-Elrahman, Stephen S G, Ferguson   +1 more
openaire   +2 more sources

Metabotropic glutamate receptors, 5 years on

Neuropharmacology, 2017
[no abstract]
Collingridge, Graham L., Manahan Vaughan, Denise, NICOLETTI, Ferdinando, Schoepp, Darryle D.   +3 more
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Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology, 2010
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the metabotropic glutamate receptor 5 (mGlu(5) receptor) and the NMDA-receptor in neurons. In rat hippocampal slices, it was shown that activation of mGlu(5) receptor by a positive modulator in the ...
Holger, Rosenbrock, Gert, Kramer, Scott, Hobson, Eliza, Koros, Marc, Grundl, Matthias, Grauert, Klaus G, Reymann, Ulrich H, Schröder   +7 more
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Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

Bioorganic & Medicinal Chemistry Letters, 2005
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)'s as low as around 100 nM were achieved.
Tasler S, Kraus M, Pegoraro S, Aschenbrenner A, Poggesi E, Testa R, MOTTA, Gaetano, Leonardi A.   +7 more
openaire   +3 more sources

Involvement of metabotropic glutamate 5 receptor in visceral pain

Pain, 2008
Metabotropic glutamate 5 receptor (mGluR5) antagonists are effective in animal models of inflammatory and neuropathic pain. The involvement of mGluR5 in visceral pain pathways from the gastrointestinal tract is as yet unknown. We evaluated effects of mGluR5 antagonists on the colorectal distension (CRD)-evoked visceromotor (VMR) and cardiovascular ...
Lindstrom, E., Brusberg, M., Hughes, P., Martin, C., Brierley, S., Phillis, B., Martinsson, R., Abrahamsson, C., Larsson, H., Martinez, V., Blackshaw, L.   +10 more
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