Results 211 to 220 of about 49,550 (244)

Biased allosteric modulators of metabotropic glutamate receptor 5

2018
The metabotropic glutamate receptor 5 is involved in numerous central nervous system disorders. New ways of targeting this receptor for therapeutic benefits involve designing compounds which bind specific areas within the receptor such that unique receptor outcomes can be achieved. My thesis focused on characterising these compounds, what they are able
openaire   +2 more sources

Extinction of a cocaine‐taking context that protects against drug‐primed reinstatement is dependent on the metabotropic glutamate 5 receptor

Addiction Biology, 2015
J. Kim, Christina J. Perry, Sophia J. Luikinga, Isabel C. Zbukvic, RobynM . Brown, A. Lawrence   +5 more
semanticscholar   +1 more source

Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias.

Parkinsonism & Related Disorders, 2014
O. Rascol, S. Fox, F. Gasparini, C. Kenney, T. Di Paolo, B. Gomez-Mancilla   +5 more
semanticscholar   +1 more source

Glutamate receptor, metabotropic, type 5

AfCS-Nature Molecule Pages, 2006
Scott R. Duncan, Peter Koulen
openaire   +2 more sources

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

Psychopharmacology, 2005
P. Kenny, B. Boutrel, F. Gasparini, G. Koob, A. Markou   +4 more
semanticscholar   +1 more source

The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems

Journal of Pharmacology and Experimental Therapeutics, 2005
M. Cowen, E. Djouma, A. Lawrence
semanticscholar   +1 more source

PET Imaging of Type 5 Metabotropic Glutamate Receptors [PDF]

, 2021
Marco Leyton, Marco Leyton, Marco Leyton, Sylvia M. L. Cox, Kelly Smart, Kelly Smart, Chawki Benkelfat, Stephanie G. Scala   +7 more
openaire   +1 more source

Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Behavioural Brain Research, 2012
M. Iijima, K. Fukumoto, S. Chaki
semanticscholar   +1 more source

Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice

Journal of Pharmacology and Experimental Therapeutics, 2006
Xia Li, A. Need, M. Baez, J. Witkin
semanticscholar   +1 more source

Metabotropic Glutamate 5 Receptor Antagonist MPEP Decreased Nicotine and Cocaine Self‐Administration but Not Nicotine and Cocaine‐Induced Facilitation of Brain Reward Function in Rats

Annals of the New York Academy of Sciences, 2003
P. Kenny, N. Paterson, B. Boutrel, S. Semenova, A. Harrison, F. Gasparini, G. Koob, P. D. Skoubis, A. Markou   +8 more
semanticscholar   +1 more source