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Coincident modulation of adenosine receptor and metabotropic glutamate receptor 5
2021Neurodegenerative disorders, such as Alzheimer’s disease are among the leading causes of death and disease burden. Therefore, new therapeutic targets are needed to treat both symptoms and disease progression. Glutamate and adenosine receptors are key proteins modulating brain cells’ activity.
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Poster #S173 METABOTROPIC GLUTAMATE RECEPTOR 5 DYSREGULATION IN SCHIZOPHRENIA
Schizophrenia Research, 2014(MBP), another myelinationand schizophrenia-related gene, is the bestcharacterized QKI mRNA ligand in mice (Larocque et al., 2002). Therefore, we tested this hypothesis using the human immature oligodendrocytic cell line, that levels of hnRNP C1 and C2 would influence the expression of these myelination-related genes. We also attempted to elucidate the
Kelly Newell +3 more
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Biased allosteric modulators of metabotropic glutamate receptor 5
2018The metabotropic glutamate receptor 5 is involved in numerous central nervous system disorders. New ways of targeting this receptor for therapeutic benefits involve designing compounds which bind specific areas within the receptor such that unique receptor outcomes can be achieved. My thesis focused on characterising these compounds, what they are able
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Glutamate receptor, metabotropic, type 5
AfCS-Nature Molecule Pages, 2006Scott Duncan, Peter Koulen
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AstroWars: the return of the astrocytic metabotropic glutamate receptor 5
The Journal of PhysiologyAbstractIn the brain, astrocytes express glutamate receptors to detect glutamatergic signalling at synapses. Numerous studies have been conducted to characterize the types and levels of receptor expression, their physiological properties and functional roles. The metabotropic glutamate receptor 5 (mGluR5) is particularly noteworthy.
José Duarte Dias +6 more
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Metabotropic Glutamate Receptor 5: A Potential Molecular Switch and Beyond
Biological Psychiatry, 2022Zhaodi Liu +3 more
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PET Imaging of Type 5 Metabotropic Glutamate Receptors
2021Stephanie G. Scala +4 more
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Metabotropic Glutamate Receptor Subtype 5 and Encephalitis (P4.316)
Neurology, 2018Caitlin Hof, Larry Burris
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