Results 31 to 40 of about 431,827 (226)

Metabotropic glutamate receptor 5 as a potential target for smoking cessation [PDF]

Psychopharmacology, 2016
Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as varenicline, that target the nicotinic receptor.
CHIAMULERA, Cristiano, MARZO, CLAUDIO MARCELLO, Balfour, David J. K.   +2 more
openaire   +4 more sources

Conformational diversity in class C GPCR positive allosteric modulation. [PDF]

Nat Commun
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G.   +11 more
europepmc   +2 more sources

Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?

Frontiers in Pharmacology, 2022
The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential therapeutic target for the treatment of several neurodegenerative diseases.
Rebecca F. Budgett, Geor Bakker, Eugenia Sergeev, Kirstie A. Bennett, Sophie J. Bradley, Sophie J. Bradley   +5 more
doaj   +1 more source

Metabotropic glutamate receptor subtype 5 antagonism in learning and memory [PDF]

European Journal of Pharmacology, 2010
The role of the metabotropic glutamate receptor 5 (mGlu(5) receptor) in learning and memory and other behaviors are reviewed by examining the influence of selective antagonists and genetic knockout on performance. This receptor is involved in spatial learning, contextual fear conditioning, inhibitory avoidance, fear potentiated startle, and conditioned
Simonyi, Agnes, Schachtman, Todd R., Christoffersen, Gert Rene Juul   +2 more
openaire   +3 more sources

Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid

Frontiers in Immunology, 2018
A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Carlos Guevara, Gonzalo Farias, Carlos Silva-Rosas, Pablo Alarcon, Gabriel Abudinen, Julio Espinoza, Andrés Caro, Heather Angus-Leppan, Heather Angus-Leppan, Heather Angus-Leppan, Jose de Grazia   +10 more
doaj   +1 more source

High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]

Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv   +1 more source

Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons

Frontiers in Cellular Neuroscience, 2021
The cellular mechanisms regulating dopamine (DA) release in the striatum have attracted much interest in recent years. By in vitro amperometric recordings in mouse striatal slices, we show that a brief (5 min) exposure to the metabotropic glutamate ...
Nicola B. Mercuri, Nicola B. Mercuri, Mauro Federici, Francesca Romana Rizzo, Lorenzo Maugeri, Sebastian L. D’Addario, Sebastian L. D’Addario, Sebastian L. D’Addario, Rossella Ventura, Rossella Ventura, Nicola Berretta   +10 more
doaj   +1 more source

Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]

arXiv, 2023
Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv  

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety [PDF]

Frontiers in Molecular Neuroscience, 2019
Amongst the many neurotransmitter systems causally linked to the expression of social behavior, glutamate appears to play a pivotal role. In particular, metabotropic glutamate 5 (mGlu5) receptors have received much attention as its altered function has been reported in several mouse models of autism spectrum disorders and mental retardation. Inhibition
Ramos-Prats A., Kolldorfer J., Paolo E., Zeidler M., Schmid G., Ferraguti F.   +5 more
openaire   +5 more sources