Results 131 to 140 of about 24,428 (229)

G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]

, 2009
Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core  

Exploring functional motions of muscarinic acetylcholine M2 receptor

, 2020
G-protein bağlı reseptörler (GPRs) en büyük sinyal protein ailesidir ve bu yüzden işleyiş mekanızmalarının altında yatan dinamik etkenlerin anlaşılması ilaç tasarımında büyük bir öneme sahiptir. Bu güne kadar yapılan pek çok çalışma olmasına rağmen, inaktif ve aktif yapılar arasında gerçekleşen kolektif konformasyonel değişimlerin özellikleri ve ...
openaire   +1 more source

A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors. [PDF]

Sci Rep
Kirchhofer SB, Jelinek V, Klingelhöfer K, Krett AL, Bünemann M.   +4 more
europepmc   +1 more source

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Cirigliano A, Amelina A, Passarini E, Ricelli A, Balasco N, Mori M, Botta B, De Stefano ME, Papotto C, Guerriero C, Tata AM, Rinaldi T.   +11 more
europepmc   +1 more source

Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside. [PDF]

J Inflamm Res
Calzetta L, Manzetti GM, Pistocchini E, Lauro RF, Gholamalishahi S, Cazzola M, Rogliani P.   +6 more
europepmc   +1 more source

Exploring the Evolving Role of Scopolamine in Pharmacotherapy: From Cognitive Impairment to Neuroplasticity?-A Narrative Review. [PDF]

Molecules
Kukla J, Olejnik P, Kasarełło K.
europepmc   +1 more source

Negative Allosteric Modulation of Agonist-Induced M₂ Muscarinic Receptor/β-Arrestin Interaction by Serum Autoantibodies from Patients with Chronic Chagas Disease. [PDF]

Cells
Carrera Páez LC, Beltrame SP, Auger SR, Sabra AH, Bilder CR, Irurzun IM, Waldner CI, Goin JC.   +7 more
europepmc   +1 more source

Bidirectional Modulation of Beam Traversal Performance by Acetylcholine in the Cerebellar Nuclei. [PDF]

J Neurosci
Iosif CI, Drake RAR, Apps R, Bashir ZI, Pickford J.   +4 more
europepmc   +1 more source

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

Pharmacological and neurophysiological aspects of space/motion sickness [PDF]

A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
core   +1 more source