Results 111 to 120 of about 13,945 (210)

Axotomy-Induced Loss of m2 Muscarinic Receptor mRNA in the Rat Facial Motor Nucleus Precedes a Decrease in Concentration of Muscarinic Receptors

, 1996
The abundance of muscarinic receptors and m2 muscarinic receptor mRNA. in the facial nuclei of rats was evaluated by autoradiographic procedures at various times up to 14 days after transection of the right facial nerve.
Baisden, Ronald H., Hoover, Donald B., Lewis, James V.   +2 more
core   +1 more source

The coupling of the M2 muscarinic receptor to its G protein is voltage dependent.

PLoS ONE, 2019
G protein coupled receptors (GPCRs) participate in the majority of signal transduction processes in the body. Specifically, the binding of an external agonist promotes coupling of the GPCR to its G protein and this, in turn, induces downstream signaling.
Yair Ben-Chaim, Chava Broide, Hanna Parnas   +2 more
doaj   +1 more source

Synergistic regulation mechanism of iperoxo and LY2119620 for muscarinic acetylcholine M2 receptor

, 2018
Dynamics correlation network was used to reveal the synergistic regulation mechanism of iperoxo and LY2119620 for muscarinic acetylcholine M2 receptor.
Quan Li, Hai-Feng Chen
core   +1 more source

Voltage dependence of M2 muscarinic receptor antagonists and allosteric modulators

Biochemical Pharmacology
Muscarinic receptors are G protein-coupled receptors (GPCRs) that play a role in various physiological functions. Previous studies have shown that these receptors, along with other GPCRs, are voltage-sensitive; both their affinity toward agonists and their activation are regulated by membrane potential.
Shimrit, Hazan, Merav, Tauber, Yair, Ben-Chaim   +2 more
openaire   +2 more sources

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptors but not m2 receptor mRNA in a human lung cell line

, 1995
1. The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. We have investigated the effect of homologous stimulation on the regulation of M2 muscarinic receptor protein and gene in human embryonic
E.‐B. Haddad, Barnes, PJ, J. Rousell, Rousell, J, Mak, JCW, Haddad, EB, J.C.W. Mak, P.J. Barnes   +7 more
core   +1 more source

Distribution of Like-muscarinic Acetylcholine Receptor M2 in the Brain of Three Castes of Polyrhachis vicina

, 2009
The cholinergic system plays an important role in the central nervous system of insects and is closely related to the complex behavior of insects. The immunohistochemical technique was performed to detect the expression of like-muscarinic acetylcholine ...
OUYANG, Xia-hui, BU, Cui-ping, LIANG, Ai-ping, XI, Geng-si   +3 more
core   +1 more source

M 1and M 3 muscarinic receptors mediate relaxation and contraction in canine nasal veins

, 2011
Background: Acetylcholine (ACh) has been shown to induce nasal congestion via vasorelaxation of intranasal posterior collecting veins (PCV) coupled with vasocontraction of extranasal outflow veins (dorsal nasal vein [DNV] and sphenopalatine vein [SPV ...
Mary A. Lung, Lung, MA
core   +1 more source

Elevated M2-muscarinic and beta 1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation

, 2015
Pathophysiologic mechanisms underlying lone atrial fibrillation (AF) have not been clearly demonstrated yet. Emerging evidence has indicated that autoimmunity may play a role in the development of AF.
AYTEMİR, KUDRET, ŞAHİNER, MEHMET LEVENT, GÜRSES, KADRİ MURAT, Kaya, Ergun B., YORGUN, HİKMET, GÜÇ, DİCLE, Ates, Ahmet Hakan, KOÇYİĞİT, DUYGU, KESİKLİ, SACİT ALTUĞ, EVRANOS, BANU, ÖZER, NECLA, Yalcin, Muhammed U., OTO, MEHMET ALİ   +12 more
core   +1 more source

Characterization of a decrease in muscarinic m2 mRNA in cerebellar granule cells by carbachol [PDF]

, 1993
Studies involving carbachol (100 microM) treatment of cerebellar granule cells for 1, 3, 6, 9, 12 and 24 hr show a decrease in the mRNA encoding for the muscarinic m2 receptor.
I. Mocchetti, W. J. Wojcik, M.A. Riva, P. Longone   +3 more
core