Results 101 to 110 of about 13,945 (210)

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?

Case Reports in Oncology, 2013
Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune
Annekathrin Haberland, Robson A.S. Santos, Ingolf Schimke, Gerd Wallukat   +3 more
doaj   +1 more source

Anti-M2 muscarinic receptor antibodies inhibit beta-adrenoceptor-mediated inotropic response in rat myocardium

, 1997
The modulation of the inotropic effect by affinity-purified antibodies against a synthetic peptide corresponding to the second extracellular loop of the human muscarinic M2 receptors was studied in adult rat ventricular myocardium.
Hjalmarson, Åke,, Hoebeke, Johan, Skomedal, T, Osnes, J B, Fu, Michael,, Schiander, I G   +5 more
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Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice [PDF]

, 2018
[Carola Romberg-Taylor credited as Carola Romberg] Rationale: Muscarinic acetylcholine receptors are known to play key roles in mediating cognitive processes, and impaired muscarinic cholinergic neurotransmission is associated with normal ageing ...
Bussey, Timothy J., Romberg-Taylor, Carola, Saksida, Lisa M., Wess, Jürgen, Bartko, Susan   +4 more
core   +1 more source

The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder

, 2005
We investigated the contractile role of M2 muscarinic receptors in mouse urinary bladder. When measured in the absence of other agents, contractions elicited to the muscarinic agonist oxotremorine-M exhibited properties consistent with that expected for ...
Taketo, Makoto M., Griffin, Michael T., Abe, Diane M., Ehlert, Frederick J., Vo, Tran H., Manabe, Toshiya, Matsui, Minoru   +6 more
core   +1 more source

Transforming growth factor-β1 induces transcriptional down-regulation of m2 muscarinic receptor gene expression

, 1996
In human embryonic lung fibroblasts, transforming growth factor-β1 (TGF- β1) induced a time-dependent down-regulation of M2 muscarinic receptor binding sites as measured with the nonselective hydrophilic ligand [2H]N- methylscopolamine (NMS).
Barnes, PJ, Rousell, J, Mak, JCW, Haddad, EB   +3 more
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Protean agonism at the muscarinic M2 receptor

, 2015
Protean agonism at the muscarinic M2 receptor De Min A. (1), Matera C. (2), Messerer R. (3), Dallanoce C. (2), Holzgrabe U. (3), Mohr K. (1) (1) University of Bonn Pharmacology and Toxicology - Bonn, Deutschland (2) University of Milan ...
A. De Min, K. Mohr, C. Matera, C.M.L. Dallanoce, R. Messerer, U. Holzgrabe   +5 more
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Effects mediated by M2 muscarinic orthosteric agonist on cell growth in human neuroblastoma cell lines [PDF]

, 2019
The role of muscarinic receptors has been largely documented over the past few decades. Recently we demonstrated that the activation of M2 muscarinic receptors arrested cell proliferation and induced apoptosis in glioblastoma and in other tumour types ...
Dini L., DINI, LUCIANA, Luciano A. M., Panzarini E., Damo E., Mattei F., Tata A. M.   +6 more
core   +1 more source

Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine

Journal of Pharmacological Sciences, 2006
.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+.
Takashi Sakamoto, Toshihiro Unno, Hayato Matsuyama, Mai Uchiyama, Mitsunobu Hattori, Masakazu Nishimura, Seiichi Komori   +6 more
doaj   +1 more source

Basenji-greyhound dog: increased m2 muscarinic receptor expression in trachealis muscle

, 1995
Airway smooth muscle from asthmatic humans and from the Basenji-greyhound dog (BG) dog is hyporesponsive to beta-adrenergic agonist stimulation. Because adenylyl cyclase is under dual regulation in airway smooth muscle, we compared muscarinic receptor ...
C. W. Emala, A. Aryana, B. B. Wolfe, R. P. Yasuda, C. A. Hirshman, S. A. Satkus, M. A. Levine   +6 more
core   +1 more source

Role of M2 muscarinic receptor in epithelial ovarian carcinoma (EOC)

, 2018
Role of M2 muscarinic receptor in epithelial ovarian carcinoma (EOC) Marilena Taggi1, M. Falcinelli1, V. Cacciamani1, V. Di Paolo1, A. M. Tata2 R.
Tata A. M, Canipari R., Taggi M, Falcinelli M, Di Paolo V, Cacciamani V   +5 more
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