Results 81 to 90 of about 12,342 (188)

67 | DYNAMICS AND INTRACELLULAR TRAFFICKING OF M2R-DUALSTERIC AGONIST COMPLEX INTO GLIOBLASTOMA CELLS

European Journal of Histochemistry
The M2 muscarinic receptor is a typical G protein–coupled receptors with inhibitory properties. Behind its canonically physiological role in the nervous system, previous studies demonstrated that its selective activation causes inhibitory effects in ...
GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
doaj   +1 more source

Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine

Journal of Pharmacological Sciences, 2006
.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+.
Takashi Sakamoto, Toshihiro Unno, Hayato Matsuyama, Mai Uchiyama, Mitsunobu Hattori, Masakazu Nishimura, Seiichi Komori   +6 more
doaj   +1 more source

The coupling of the M2 muscarinic receptor to its G protein is voltage dependent.

PLoS ONE, 2019
G protein coupled receptors (GPCRs) participate in the majority of signal transduction processes in the body. Specifically, the binding of an external agonist promotes coupling of the GPCR to its G protein and this, in turn, induces downstream signaling.
Yair Ben-Chaim, Chava Broide, Hanna Parnas   +2 more
doaj   +1 more source

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Voltage dependence of M2 muscarinic receptor antagonists and allosteric modulators

Biochemical Pharmacology
Muscarinic receptors are G protein-coupled receptors (GPCRs) that play a role in various physiological functions. Previous studies have shown that these receptors, along with other GPCRs, are voltage-sensitive; both their affinity toward agonists and their activation are regulated by membrane potential.
Shimrit, Hazan, Merav, Tauber, Yair, Ben-Chaim   +2 more
openaire   +2 more sources

A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors. [PDF]

Sci Rep
Kirchhofer SB, Jelinek V, Klingelhöfer K, Krett AL, Bünemann M.   +4 more
europepmc   +1 more source

Receptor architecture of the macaque lateral geniculate nucleus. [PDF]

Brain Struct Funct
Saito M, Rapan L, Niu M, Zhao L, Tsujimura SI, Takemura H, Palomero-Gallagher N.   +6 more
europepmc   +1 more source

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells. [PDF]

J Neurochem
Guerriero C, De Nuccio C, Petrone M, Rinaldi T, Cirigliano A, Visentin S, Bernardo A, Conti L, Matera C, De Amici M, Dallanoce C, Tata AM.   +11 more
europepmc   +1 more source

Acetylcholine in Brain-Body Communication: Biological Mechanisms and Physiological Roles. [PDF]

Int J Mol Sci
Gao Y, Zhou T, Lai X, Fei E.
europepmc   +1 more source

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Cirigliano A, Amelina A, Passarini E, Ricelli A, Balasco N, Mori M, Botta B, De Stefano ME, Papotto C, Guerriero C, Tata AM, Rinaldi T.   +11 more
europepmc   +1 more source