Results 71 to 80 of about 12,342 (188)

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1048-1060, August 2026.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain

Neuroscience, 1986
The distribution of M1 and M2 muscarine receptors in the rat brain was investigated by in vitro autoradiography. Muscarine receptors were visualized after complete receptor uncoupling in ethylenediaminetetraacetic acid buffer containing 1 mM N-ethyl maleimide and saturation with the ligand [3H]quinuclidinyl benzilate.
D C, Mash, L T, Potter
openaire   +2 more sources

Acetylcholine-induced inhibition of presynaptic calcium signals and transmitter release in the frog neuromuscular junction

Frontiers in Physiology, 2016
Acetylcholine (ACh), released from axonal terminals of motor neurones in neuromuscular junctions regulates the efficacy of neurotransmission through activation of presynaptic nicotinic and muscarinic autoreceptors.
Eduard Khaziev, Eduard Khaziev, Eduard Khaziev, Dmitry Samigullin, Dmitry Samigullin, Dmitry Samigullin, Nikita Zhilyakov, Nikita Zhilyakov, Nijaz Fatikhov, Ellya Bukharaeva, Ellya Bukharaeva, Alexej Verkhratsky, Evgeny Nikolsky, Evgeny Nikolsky, Evgeny Nikolsky   +14 more
doaj   +1 more source

Chemogenetic Activation of G12 Signaling Thickens the Epidermis With Enhanced Barrier Function

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
In this study, we investigated the role of G12 signaling in the epidermis using a keratinocyte‐specific chemogenetic approach. Activation of G12 signaling promoted keratinocyte differentiation and enhanced epidermal barrier function by upregulating filaggrin, claudin‐1, and ceramide.
Nozomi Kamakura, Natsumi Hirai, Kaito Arai, Yaxin Du, Toshiaki Kogame, Yusuke Ohno, Akio Kihara, Kenji Kabashima, Asuka Inoue   +8 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome

Molecular Pain, 2018
Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic‐2 acetylcholine (M2) receptor.
Veronica I Shubayev, Alex Y Strongin, Tony L Yaksh   +2 more
doaj   +1 more source

Effects of AF-DX116 and Other Muscarinic Receptor Antagonists on Orthostatic Hypotension in Autonomic Imbalanced (SART-Stressed) Rats

Journal of Pharmacological Sciences, 2005
SART (specific alternation of rhythm in temperature)-stressed rats are an animal model of autonomic imbalance created by exposing animals to repeated cold stress. The SART-stressed rats have been shown to easily develop orthostatic hypotension (OH).
Taeko Hata, Yoshinori Funakami, Eiji Itoh   +2 more
doaj   +1 more source

Effect of inflammatory cell mediators on M2 muscarinic receptors in the lungs

Life Sciences, 1993
Acetylcholine released from vagal nerve endings constricts airways by stimulating M3 muscarinic receptors on the airway smooth muscle. At the same time, released acetylcholine feeds back onto inhibitory M2 muscarinic autoreceptors on the nerve endings, limiting further release of acetylcholine.
A D, Fryer, D B, Jacoby
openaire   +2 more sources

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?

Case Reports in Oncology, 2013
Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune
Annekathrin Haberland, Robson A.S. Santos, Ingolf Schimke, Gerd Wallukat   +3 more
doaj   +1 more source