Results 61 to 70 of about 12,342 (188)

The M2 Muscarinic G-protein-coupled Receptor Is Voltage-sensitive [PDF]

Journal of Biological Chemistry, 2003
G-protein coupled receptors are not considered to exhibit voltage sensitivity. Here, using Xenopus oocytes, we show that the M2 muscarinic receptor (m2R) is voltage-sensitive. The m2R-mediated potassium channel (GIRK) currents were used to assay the activity of m2R.
Yair, Ben-Chaim, Oded, Tour, Nathan, Dascal, Itzchak, Parnas, Hanna, Parnas   +4 more
openaire   +2 more sources

Is Aripiprazole an Effective Adjunct to Reduce Metabolic Adverse Effects Caused by Clozapine in Patients With Schizophrenia—A Systematic Review

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Adjunctive aripiprazole may provide modest improvements in lipid parameters and body weight in clozapine‐treated patients with schizophrenia, but evidence for glucose and waist circumference outcomes remains limited. Larger, long‐term randomized controlled trials are needed.
Avtaar Singh, Soban Sadiq
wiley   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

Carbachol-Induced Secretion and Homologous Desensitization in Rat Basophilic Leukemia (RBL-2H3) Cells Transfected With Human m2 Muscarinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2004
Carbachol (CCh) caused a dose-dependent release of β-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).
Kazuhiko Oishi, Akihiro Sakurai, Noriyasu Seki, Tomokazu Yoshizumi, Masaatsu K. Uchida   +4 more
doaj   +1 more source

Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children. [PDF]

PLoS ONE, 2011
OBJECTIVE: The presence of autoantibodies with adrenergic and cholinergic activity, capable of triggering neurotransmitter receptor-mediated effects, has been associated with pathogenesis in T. cruzi-infected hosts.
Romina A Cutrullis, Guillermo F Moscatelli, Samanta Moroni, Bibiana J Volta, Rita L Cardoni, Jaime M Altcheh, Ricardo S Corral, Héctor L Freilij, Patricia B Petray   +8 more
doaj   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

Effects mediated by the α7 nicotinic acetylcholine receptor on cell proliferation and migration in rat adipose-derived stem cells

European Journal of Histochemistry, 2020
Adipose-derived stem cells (ASCs) are an attractive source for regenerative medicine as they can be easily isolated, rapidly expandable in culture and show excellent in vitro differentiation potential.
Marta Pernarella, Roberta Piovesana, Carlo Matera, Alessandro Faroni, Mario Fiore, Luciana Dini, Adam J. Reid, Clelia Dallanoce, Ada Maria Tata   +8 more
doaj   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival

Cells, 2020
Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key feature of malignant gliomas is their cellular heterogeneity. In particular, the presence of an undifferentiated cell population of defined Glioblastoma Stem cells (
Ilaria Cristofaro, Francesco Alessandrini, Zaira Spinello, Claudia Guerriero, Mario Fiore, Elisa Caffarelli, Pietro Laneve, Luciana Dini, Luciano Conti, Ada Maria Tata   +9 more
doaj   +1 more source

Parasympathetic Tone Selectively Modulates Electrogram Fragmentation and Spectral Properties in Right Atrial Ganglionated Plexi

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Electrogram fragmentation and spectral EGMs features in GPs area are selectively modulated by parasympathetic tone, as demonstrated by high‐density right atrial mapping before and after vagal blockade. EGMs, bipolar atrial electrograms; GPs, ganglionated plexi; RA, right atrium.
Andrea Giomi, Andrea Bernardini, Alessandro Paoletti Perini, Margherita Padeletti, Cristiano Salvatore Zaccaria, Federica Michelotti, Umberto Signorini, Rossella Marcucci, Massimo Milli   +8 more
wiley   +1 more source