Results 191 to 200 of about 24,428 (229)
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Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo
Naunyn-Schmiedeberg's Archives of Pharmacology, 1988The antimuscarinic effects of methoctramine (N, N'-bis[6-[(2-methoxybenzyl)amino]hexyl]-1, 8-octanediamine tetrahydrochloride), a polymethylene tetraamine endowed with high cardioselectivity in vitro, were assessed in two in vivo preparations. Methoctramine (300 micrograms/kg i.v.) strongly inhibited the methacholine- and muscarine-induced bradycardia ...
J, Wess +5 more
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Kinetic and biophysical analysis of the m2 muscarinic receptor
Life Sciences, 1995The recombinant Pm2 muscarinic receptor expressed in Chinese hamster ovary (CHO) cells was used as a model system to examine receptor-effector coupling and ligand binding. In CHO cells, equilibrium binding studies and the dependence on receptor number per cell of the maximum response and EC50 values for agonist stimulation of phosphatidylinositol ...
B T, Hirschberg +6 more
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Muscarinic M1, M2 receptor binding. Relationship with functional efficacy
European Journal of Pharmacology, 1988A comparison has been made between [3H]pirenzepine binding to the M1 receptor population of rat cerebral cortex and [3H]N-methylscopolamine binding to M2 receptors in rat cardiac membranes. Several standard muscarinic antagonists including trihexyphenidyl HCl, benztropine, biperidin and 4-DAMP (4-diphenylacetoxy-N-methyl piperidine methiodide) showed ...
S B, Freedman, M S, Beer, E A, Harley
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Life Sciences, 1990
A selective amplification of the coding sequence of the rat M2 muscarinic receptor gene was achieved by the polymerase chain reaction. The error rate of this amplification system under conditions specified was 1 nucleotide substitution in 841 base pairs.
J, Lai +3 more
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A selective amplification of the coding sequence of the rat M2 muscarinic receptor gene was achieved by the polymerase chain reaction. The error rate of this amplification system under conditions specified was 1 nucleotide substitution in 841 base pairs.
J, Lai +3 more
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A novel function of the M2 muscarinic receptor
Trends in Pharmacological SciencesThe M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment.
Jürgen Wess, Liu Liu
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Muscarinic M2 receptor synthesis: study of receptor turnover with propylbenzilylcholine mustard
European Journal of Pharmacology: Molecular Pharmacology, 1995We have investigated the rate and the functional responsiveness of the newly synthesised M2 muscarinic receptors in HEL 299 cells following propylbenzilylcholine mustard treatment at 37 degrees C. Propylbenzilylcholine mustard induced a dose-dependent loss of the hydrophilic ligand [3H]N-methylscopolamine binding sites with 80% inactivation at 0.1 ...
E B, Haddad, J, Rousell, P J, Barnes
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Distribution of m2 muscarinic receptors in rat brain using antisera selective for m2 receptors.
Molecular Pharmacology, 1991The DNA fragment encoding the third intracellular loop of rat m2 muscarinic receptor was fused to the gene for staphylococcal Protein A. The resultant fusion protein, expressed in bacteria, was purified via IgG affinity chromatography and used as an antigen to raise a polyclonal antiserum.
M, Li +4 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 1992
The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved.
S A, Darroch, L K, Choo, F, Mitchelson
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The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved.
S A, Darroch, L K, Choo, F, Mitchelson
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Immunohistochemical localization of muscarinic receptors (M2) in the rat skin
Cell and Tissue Research, 2000Acetylcholine (ACh) produces pain when applied to human skin and excites cutaneous mechanoreceptors and nerve terminals. These effects are partially mediated by activation of muscarinic receptors. The expression of muscarinic receptor subtype M2 has been shown in sensory neurons of rat dorsal root ganglia using reverse transcriptase polymerase chain ...
R V, Haberberger, M, Bodenbenner
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Anti-M2 muscarinic receptor autoantibodies and idiopathic dilated cardiomyopathy
International Journal of Cardiology, 1996Idiopathic dilated cardiomyopathy is an often fatal cause of heart failure and has been intensively studied over the last 50 years. One of the main mechanisms for this disease is likely to be autoimmunity-mediated myocardial damage. So far, a variety of autoantibodies have been detected against a number of putative cardiac autoantigens in the sera of ...
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