Results 201 to 210 of about 13,945 (210)
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Astrocytes have both M1 and M2 muscarinic receptor subtypes
Brain Research, 1986In astrocytes, carbachol evoked the turnover of membrane inositol phospholipids prelabelled with [3H]inositol, as revealed by [3H]inositol phosphate accumulation in the presence of 5 mM lithium. This effect was blocked by atropine and by pirenzepine (IC50 2.2 nM and 56 nM, respectively).
S, Murphy, B, Pearce, C, Morrow
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Expression of the Human Muscarinic Receptor Gene m2 in Dictyostelium discoideum
Nature Biotechnology, 1995We have expressed a functional human muscarinic M2 receptor, under the control of the homologous discoidin I gamma promoter, in the cellular slime mold Dictyostelium discoideum. The use of a contact site A leader peptide ensured insertion of the newly synthesized receptor protein into the plasma membrane.
G, Voith, T, Dingermann
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Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors
Biochemical Pharmacology, 1996Muscarinic receptors of the m2 subtype expressed in Chinese hamster ovary cells were labeled with [methyl-3H]acetylcholine([3H]ACh), and the rate of dissociation in the presence and absence of several compounds known to exert allosteric effects on labeled antagonist binding was observed.
A, Gnagey, J, Ellis
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Functional role of M2 muscarinic receptors in the guinea pig ileum
Life Sciences, 1995Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation elicited by the beta-adrenergic ...
F J, Ehlert, E A, Thomas
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Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor
Nature, 1986Acetylcholine (ACh) is considered to act as a neurotransmitter in the mammalian brain by binding to membrane receptors and bringing about a change in neurone excitability. In the case of muscarinic receptors, cell excitability is usually increased; this effect results from a closure of membrane potassium channels in cortical cells.
T M, Egan, R A, North
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Studies on muscarinic M2 receptors in smooth muscle.
Proceedings of the Western Pharmacology Society, 2000Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C.
F, Mitchelson, A, Shen
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Homologous and heterologous regulation of M2 muscarinic receptors and m2 receptor gene expression
Life Sciences, 1995E-B. Haddad +3 more
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Co-operative potential of M2 muscarinic receptors
Life Sciences, 1999C.S. Sum, J.W. Wells
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Altered distribution of M2 and M4 muscarinic receptor expression in vitiligo
The Journal of Dermatology, 2010Sirintip, Chaichalotornkul +4 more
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