Results 201 to 210 of about 24,286 (211)

Anti-M2 muscarinic receptor autoantibodies and idiopathic dilated cardiomyopathy

International Journal of Cardiology, 1996
Idiopathic dilated cardiomyopathy is an often fatal cause of heart failure and has been intensively studied over the last 50 years. One of the main mechanisms for this disease is likely to be autoimmunity-mediated myocardial damage. So far, a variety of autoantibodies have been detected against a number of putative cardiac autoantigens in the sera of ...
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Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes

Journal of Neuroimmunology, 1994
The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype.
Costa, P, Castoldi, A. F, Traver, D. J, Costa, L. G.   +3 more
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Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor

Bioorganic & Medicinal Chemistry Letters, 2000
Structure activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-alpha-[4-[[4-methoxyphenyl(S)-sufinyl]phenyl]-1-pi perazineacetonitrile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold.
J A, Kozlowski, D B, Lowe, H S, Guzik, G, Zhou, V B, Ruperto, R A, Duffy, R, McQuade, G, Crosby, L A, Taylor, W, Billard, H, Binch, J E, Lachowicz   +11 more
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Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization

Life Sciences, 1982
Abstract The heterogeneity of muscarinic receptors was examined in sympathetic ganglia and atria by “in vitro” binding techniques and functional studies. As tools we have used the classical antagonist atropine, the selective antagonist pirenzepine and the unique muscarinic agonist McN-A-343.
R, Hammer, A, Giachetti
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Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995
The relative distribution and absolute quantities of muscarinic receptor subtypes m1, m2, m3, and m4 were determined in membranes of canine trachealis muscle, bronchi, and lung parenchyma by immuno-precipitation with receptor subtype-specific rabbit polyclonal antisera. Additionally, the functional coupling of muscarinic receptors to the inhibition of
C W, Emala, A, Aryana, M A, Levine, R P, Yasuda, S A, Satkus, B B, Wolfe, C A, Hirshman   +6 more
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Protean agonism at the muscarinic M2 receptor

2015
Protean agonism at the muscarinic M2 receptor De Min A. (1), Matera C. (2), Messerer R. (3), Dallanoce C. (2), Holzgrabe U. (3), Mohr K. (1) (1) University of Bonn Pharmacology and Toxicology - Bonn, Deutschland (2) University of Milan Pharmaceutical Sciences - Milan, Italien (3) University of Würzburg Pharmaceutical and Medicinal Chemistry - Wu ...
A. De Min, C. Matera, R. Messerer, C.M.L. Dallanoce, U. Holzgrabe, K. Mohr   +5 more
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Studies on muscarinic M2 receptors in smooth muscle.

Proceedings of the Western Pharmacology Society, 2000
Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C.
F, Mitchelson, A, Shen
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cis-Methyldioxolane specifically recognizes the m2 muscarinic receptor.

Journal of neurochemistry, 1994
cis-Methyldioxolane (CD) is a muscarinic receptor agonist. [3H]CD has been used to label a subpopulation of muscarinic receptors described as exhibiting high agonist affinity. Pharmacological evidence suggests that the population of receptors labeled by [3H]CD consists of m2 and/or m4 subtypes; however, no studies have directly addressed the subtype ...
R A, Huff, M B, Abou-Donia
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Co-operative potential of M2 muscarinic receptors

Life Sciences, 1999
C.S. Sum, J.W. Wells
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Homologous and heterologous regulation of M2 muscarinic receptors and m2 receptor gene expression

Life Sciences, 1995
E-B. Haddad, J. Rousell, J.C.W. Mak, P.J. Barnes   +3 more
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