Results 131 to 140 of about 18,237 (210)

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

The Journal of Clinical Hypertension
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP).
Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu   +22 more
doaj   +1 more source

Quantitative surface field analysis: learning causal models to predict ligand binding affinity and pose. [PDF]

, 2018
We introduce the QuanSA method for inducing physically meaningful field-based models of ligand binding pockets based on structure-activity data alone. The method is closely related to the QMOD approach, substituting a learned scoring field for a pocket ...
Cleves, Ann E, Jain, Ajay N
core  

Pharmacological and neurophysiological aspects of space/motion sickness [PDF]

A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
core   +1 more source

Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma

Tuberculosis and Respiratory Diseases, 2019
Background Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly has not been clearly verified.
Ji Young Kang, M.D., Ph.D., In Kyoung Kim, Ph.D., Jung Hur, Ph.D., Seok Chan Kim, M.D., Ph.D., Sook Young Lee, M.D., Ph.D., Soon Seog Kwon, M.D., Ph.D., Young Kyoon Kim, M.D., Ph.D.   +6 more
doaj  

Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors. [PDF]

, 2011
BACKGROUND: Enteric neurotransmitters that act at G protein-coupled receptors (GPCRs) are well known to acutely promote epithelial Cl(-) and fluid secretion.
Bertelsen, Lone S, Frankson, Michelle, Keely, Stephen J, Kelly, Orlaith B, Mroz, Magdalena S, Toumi, Ferial, Ward, Joseph B   +6 more
core   +1 more source

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]

, 2020
Chess-Williams, Russ, McDermott, Catherine, Sellers, Donna J, West, Eliza   +3 more
core   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. [PDF]

Mol Cancer
Zhang C, Guo X, Wang Y, Zhang S, Wang Z.
europepmc   +1 more source

Rational Use of Bethanechol in Dogs and Cats with Bladder Dysfunction. [PDF]

Vet Sci
Galluzzi F, Menozzi A, Saleri R, De Rensis F, Spattini G.   +4 more
europepmc   +1 more source

Induction of chronic prostatitis does not alter the innate contractile properties of the prostate or urethra in rats. [PDF]

Sci Rep
Aydogdu O, Black G, Aronsson P, Carlsson T, Winder M.   +4 more
europepmc   +1 more source

Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae. [PDF]

Sci Rep
Klein V, Michely A, Hempel P, Katona I, Tenbrock K, Martin C, Verjans E.   +6 more
europepmc   +1 more source