Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato +5 more
doaj +4 more sources
Nerve growth factor receptors in dementia [PDF]
TURKISH JOURNAL OF MEDICAL SCIENCES, 2015 Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids.
Manoochehr Messripour +3 more
openaire +5 more sources
Nerve growth factor and its receptor in schizophrenia
BBA Clinical, 2014 Promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. We aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (NGF) and its receptor (NGFR) in the ...
R. Zakharyan +3 more
semanticscholar +4 more sources
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
eLife, 2016 Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator.
Xiang Zhou +12 more
doaj +2 more sources
The expression of follicle-stimulating hormone receptor (FSHR) and nerve growth factor (NGF) in endometriomas [PDF]
Archives of Medical ScienceIntroduction Material and methods Results ...
Susan Afshari-Stasiak +5 more
doaj +2 more sources
Human Melanoma Initiating Cells Express Neural Crest Nerve Growth Factor Receptor CD271 [PDF]
Nature, 2010 The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years. Here we show that in melanomas, tumour stem cells (MTSCs, for melanoma tumour stem cells) can be isolated prospectively as a highly enriched ...
A. D. Boiko +11 more
semanticscholar +4 more sources
Binding of nerve growth factor receptor in sympathetic ganglia. [PDF]
Proceedings of the National Academy of Sciences, 1973 (125)I-Labeled nerve growth factor binds to membrane preparations from superior cervical ganglia of rabbit in a specific fashion indicative of an interaction with the physiological receptor.
S. Banerjee +3 more
semanticscholar +4 more sources
Norepinephrine regulates epithelial-derived neurotrophins expression and sensory nerve regeneration through ADRB2 receptor [PDF]
Communications BiologyNorepinephrine (NE) is mainly released by sympathetic nerve terminals to act on organs and tissues. After corneal epithelial debridement, we found that the sympathetic nerve fibers penetrated the limbus and regenerated toward the cornea within 24 h post ...
Xingyue Yuan +10 more
doaj +2 more sources
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain [PDF]
Molecular Pain, 2010 Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target for
Bloom Aaron P +6 more
doaj +4 more sources
Nature Cell Biology, 2023 The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated.
Xiang Gao +15 more
semanticscholar +1 more source