Results 1 to 10 of about 2,401,973 (191)

Notch1 regulates hippocampal plasticity through interaction with the Reelin pathway, glutamatergic transmission and CREB signaling [PDF]

Frontiers in Cellular Neuroscience, 2015
Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in
Emanuele eBrai, Swananda eMarathe, Simone eAstori, Naila eBen Fredj, Elisabeth ePerry, Christophe eLamy, Alessandra eScotti, Lavinia eAlberi   +7 more
doaj   +6 more sources

Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model

Stem Cell Research & Therapy, 2021
Background Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signaling pathway network involved in ...
Mi Chen, Chenxia Lu, Hanwen Lu, Junyi Zhang, Dan Qin, Shenghui Liu, Xiaodong Li, Lisheng Zhang   +7 more
doaj   +2 more sources

Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells

Frontiers in Immunology, 2019
Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion.
Claudia Sorrentino, Fokhrul Hossain, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Lucio Miele, Silvana Morello   +9 more
doaj   +2 more sources

Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity [PDF]

Frontiers in Immunology
BackgroundCervical cancer is the fourth most common malignancy in women globally. The NOTCH signaling pathway is aberrantly activated in multiple tumors, and NOTCH1, its core transmembrane receptor, is highly expressed in cervical cancer. However, NOTCH1’
Aihua Guo, Zhixiong Su, Enhuan Zhang, Huaqin Lin, Peilin Zhong, Zhiyuan Xie, Qingzhen Zhan, Ting Ye, Ting Ye, Ting Ye, Yang Sun   +10 more
doaj   +2 more sources

High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma

Tumor Biology, 2017
C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong, Haiwei Wu, Zhong Guo, Tao Qin, Yang Xu, Hua Jing, Yanqing Wang, Yi Shen   +7 more
doaj   +2 more sources

A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth

Frontiers in Pharmacology, 2023
Although breast cancer stem cells (BCSCs) are well characterized, molecularly targeting and eradicating this sub-population remains a challenge in the clinic.
Uttara Saran, Balaji Chandrasekaran, Ashish Tyagi, Vaibhav Shukla, Amandeep Singh, Arun K. Sharma, Chendil Damodaran   +6 more
doaj   +2 more sources

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate

Nature Communications
Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with hematopoietic progenitors (HPC).
Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J. Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas   +18 more
doaj   +2 more sources

Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.

PLoS ONE, 2015
Angiogenesis, a marker of cancer development, affects response to radiotherapy sensibility. This preclinical study aims to understand the receptor tyrosine kinase-mediated angiogenesis in head neck squamous cell carcinoma (HNSCC).
Wei-Ming Wang, Zhi-Li Zhao, Si-Rui Ma, Guang-Tao Yu, Bing Liu, Lu Zhang, Wen-Feng Zhang, Ashok B Kulkarni, Zhi-Jun Sun, Yi-Fang Zhao   +9 more
doaj   +2 more sources

Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

eLife
In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic transformation.
Elazar Besser, Anat Gelfand, Shiri Procaccia, Paula Berman, David Meiri   +4 more
doaj   +2 more sources

NOTCH1 is a mechanosensor in adult arteries

Nature Communications, 2017
Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity ...
Julia J Mack, Thiago S Mosqueiro, Brian J Archer   +2 more
exaly   +2 more sources