Notch1 regulates hippocampal plasticity through interaction with the Reelin pathway, glutamatergic transmission and CREB signaling [PDF]
Frontiers in Cellular Neuroscience, 2015 Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in
Emanuele eBrai +7 more
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The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress [PDF]
Life Science AllianceFluid shear stress mechanotransduction by Notch1: flow stimulates Notch1 intracellular domain interactions to polarize receptors into microdomains, driving endocytosis and proteolytic activation.
Tania Singh +3 more
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Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity [PDF]
Frontiers in ImmunologyBackgroundCervical cancer is the fourth most common malignancy in women globally. The NOTCH signaling pathway is aberrantly activated in multiple tumors, and NOTCH1, its core transmembrane receptor, is highly expressed in cervical cancer. However, NOTCH1’
Aihua Guo +10 more
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Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
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The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis
Scientific Reports, 2023 Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis, differentiation and proliferation. It was reported that Notch1 receptor negatively regulates mouse osteoclast development and formation by inhibiting the ...
Costanzo Padovano +12 more
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Optogenetic control of NOTCH1 signaling
Cell Communication and Signaling, 2022 The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases.
Joanna Kałafut +6 more
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NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia
Frontiers in Oncology, 2022 NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).
Jennifer Edelmann
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Cell Death Discovery, 2022 Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li +9 more
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A Review on Notch Signaling and Colorectal Cancer
Cells, 2020 Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway.
Ashish Tyagi +2 more
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Notch1 signaling is limited in healthy mature kidneys in vivo
BMC Research Notes, 2023 Objective A Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1 signaling is crucial to these pathogeneses, the basal signaling level in ‘healthy’ mature ...
Ryosuke Sugiura +6 more
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