Results 91 to 100 of about 83,203 (255)
Genomics, 2020 Fanconi Anemia (FA) is an inherited bone marrow failure syndrome caused by mutation in FA pathway proteins, involved in Interstrand Cross Link (ICL) repair. FA cells exhibit in vitro proliferation arrest due to accumulated DNA damage, hence understanding the rescue mechanism that renders proliferation advantage is required.
Binita, Zipporah E +6 more
openaire +2 more sources
Head &Neck, EarlyView.ABSTRACT Background Sinonasal adenoid cystic carcinoma (AdCC) has a limited prognosis. This study assesses its incidence and prognostic factors in The Netherlands, focusing on histopathological features. Methods Adult patients diagnosed during 2008–2022 were retrieved through the Netherlands Cancer Registry and the Dutch Pathology Registry.
Lise J. van de Velde +9 more
wiley +1 more source
A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche
Haematologica, 2019 Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting ...
Lijian Shao +12 more
doaj +1 more source
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]
, 1996 Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C. +6 more
core
Head &Neck, EarlyView.ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili +16 more
wiley +1 more source
International Journal of Molecular Medicine, 2017 Intestinal ischemia/reperfusion (I/R) induces disruption of the intestinal barrier function. Aryl hydrocarbon receptor (AhR) has a vital role in maintaining the intestinal barrier function. However, the precise mechanism by which AhR maintains intestinal barrier function remains unclear. Notch1 signaling is downstream of AhR, and has also been reported
Liu, Zhongze +10 more
openaire +3 more sources
Fibroblast Growth Factor Receptor Signaling Promotes Radial Glial Identity and Interacts with Notch1 Signaling in Telencephalic Progenitors [PDF]
The Journal of Neuroscience, 2004 The Notch and fibroblast growth factor (FGF) pathways both regulate cell fate specification during mammalian neural development. We have shown previously that Notch1 activation in the murine forebrain promotes radial glial identity. This result, together with recent evidence that radial glia can be progenitors, suggested that Notch1 signaling might ...
Yoon, Keejung +5 more
openaire +3 more sources
NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice.
PLoS ONE, 2013 NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-membrane receptors. NOTCH signaling is highly conserved in evolution and mediates communication between adjacent cells.
Zaohua Huang +2 more
doaj +1 more source
iMeta, EarlyView.The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang +13 more
wiley +1 more source
Implications of Notch Signaling in Taste Cell Replacement [PDF]
, 2017 Cyclophosphamide (CYP) was one of the first chemotherapy drugs developed and used to treat several types of cancer, by disrupting proliferative cells. Unfortunately, CYP is unable to differentiate between cancerous cells and healthy cells turning over ...
D\u27Alessandro, Nicholas B
core +1 more source