Results 141 to 150 of about 2,402,104 (309)

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

Mesenchymal Stem Cell‐Mediated Vascular Regeneration in Diabetic Foot Ulcers via the Notch Signaling Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the experimental design and key findings of the study on the role of mesenchymal stem cells (MSCs) and Notch signaling in diabetic foot ulcer (DFU) healing. The study involved five groups of BALB/c mice: Control, Model, MSCs Treatment, MSCs + Notch Inhibition, and MSCs + Notch Activation.
Feifei Li, Li Xu, Xin Hou, Dengfeng Zhu, Jingming Ou, Zuwei Yang, Yuhong Gu   +6 more
wiley   +1 more source

N 6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis

Cardiovascular Diabetology
Background N 6-methyladenosine (m6A) modification of messenger RNA (mRNA) is crucial for liquid-liquid phase separation in mammals. Increasing evidence indicates that liquid-liquid phase separation in proteins and RNAs affects diabetic cardiomyopathy ...
Zhi-Yan Liu, Li-Chan Lin, Zhen-Yu Liu, Kai Song, Bin Tu, He Sun, Yang Zhou, Sui Mao, Ye Zhang, Rui Li, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao   +12 more
doaj   +1 more source

Role of Notch1 in the arterial specification and angiogenic potential of mouse embryonic stem cell-derived endothelial cells

Stem Cell Research & Therapy, 2018
Background Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are ...
Jae Kyung Park, Tae Wook Lee, Eun Kyoung Do, Hye Ji Moon, Jae Ho Kim   +4 more
doaj   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

5-hydroxymethylcytosine is a key epigenetic regulator of keratinocyte stem cells during psoriasis pathogenesis [PDF]

, 2019
Epigenetic regulation is now known to play an important role in determining stem cell fate during normal tissue development and disease pathogenesis. In this study, we report loss of 5-hydroxymethylcytosine (5-hmC) mediated by ten-eleven translocation ...
Yuan, Christine Wan-Yin
core  

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

Protein & Cell
Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail.
Wei Ma, Lu Zhang, Weilong Chen, Zhaoxia Chang, Juchuanli Tu, Yuanyuan Qin, Yuwen Yao, Mengxue Dong, J. Ding, Siqin Li, Fengkai Li, Qiaodan Deng, Yifei Yang, Tingting Feng, Fanrong Zhang, Xiying Shao, Xueyan He, Lixing Zhang, Guohong Hu, Quentin Liu, Yizhou Jiang, Shu Zhu, Zhi Xiao, Dan Su, Tong Liu, Suling Liu   +25 more
semanticscholar   +1 more source

Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and microbial dysbiosis. Recent studies have highlighted the multifaceted roles of antimicrobial peptides (AMPs) both as innate defenders against microbial invasion and as regulators of immune responses and skin barrier ...
Ge Peng, Alafate Abudouwanli, Quan Sun, Yi Tan, Wanchen Zhao, Mengyao Yang, Shan Wang, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +9 more
wiley   +1 more source