Results 11 to 20 of about 83,203 (255)
Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells [PDF]
Frontiers in Immunology, 2019 Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion.
Claudia Sorrentino +9 more
doaj +4 more sources
PLoS ONE, 2010 BackgroundNotch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms.
Miguel Aste-Amézaga +29 more
doaj +5 more sources
Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways [PDF]
iScience, 2021 The anti-CD20 monoclonal antibodies rituximab and obinutuzumab differ in their mechanisms of action, with obinutuzumab evoking greater direct B cell death. To characterize the signaling processes responsible for improved B cell killing by obinutuzumab, we undertook a phosphoproteomics approach and demonstrate that rituximab and obinutuzumab ...
Jennifer Edelmann +10 more
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Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain [PDF]
Journal of Biological Chemistry, 2003 The cell fate determinant Numb influences developmental decisions by antagonizing the Notch signaling pathway. However, the underlying molecular mechanism of this inhibition is poorly understood. Here we report that the mammalian Numb protein promotes the ubiquitination of membrane-bound Notch1 receptor.
Melanie A, McGill, C Jane, McGlade
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Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling [PDF]
Cardiovascular Drugs and Therapy, 2020 Oestrogen receptor β is believed to exert a cardioprotective effect against ischaemic injury. Nonetheless, the mechanism underlying its protective action remains to be fully elucidated. Recently, increased attention has been focused on Notch1 signalling for ameliorating cardiac ischaemic injury.
Mingjun Du +5 more
openaire +2 more sources
DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation [PDF]
Journal of Biological Chemistry, 2011 DDR1 (discoidin domain receptor tyrosine kinase 1) kinase s highly expressed in a variety of human cancers and occasionally mutated in lung cancer and leukemia. It is now clear that aberrant signaling through the DDR1 receptor is closely associated with various steps of tumorigenesis, although little is known about the molecular mechanism(s) underlying
Hyung-Gu, Kim +4 more
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Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling [PDF]
Journal of Korean Neurosurgical Society, 2018 Notch receptors are heterodimeric transmembrane proteins that regulate cell fate, such as differentiation, proliferation, and apoptosis. Dysregulated Notch pathway signaling has been observed in glioblastomas, as well as in other human malignancies. Nerve growth factor (NGF) is essential for cell growth and differentiation in the nervous system. Recent
Park, Jun Chul +6 more
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The Notch1 receptor is cleaved constitutively by a furin-like convertase [PDF]
Proceedings of the National Academy of Sciences, 1998 The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that proteolytic processing of p300 is an essential step in the formation of the biologically active receptor because only the cleaved fragments are present at the cell ...
Logeat, F. +6 more
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Sequential Signaling through Notch1 and erbB Receptors Mediates Radial Glia Differentiation [PDF]
The Journal of Neuroscience, 2003 Radial glia cells both generate neurons and physically guide nascent neurons to their target destination in the cortex, and as such they are essential for CNS development. It has been proposed that in the developing cerebellum, neuronal contact induces radial glia formation, however, the mechanisms involved in this process are not well understood. Here
Brooke A, Patten +3 more
openaire +2 more sources
Stem Cell Research & Therapy, 2021 Background Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signaling pathway network involved in ...
Mi Chen +7 more
doaj +1 more source