Results 11 to 20 of about 2,402,104 (309)

Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling [PDF]

Cardiovascular Drugs and Therapy, 2020
Purpose Oestrogen receptor β is believed to exert a cardioprotective effect against ischaemic injury. Nonetheless, the mechanism underlying its protective action remains to be fully elucidated.
Mingjun Du, J. Shan, Anqi Feng, Sebastian Schmull, Jianmin Gu, S. Xue   +5 more
semanticscholar   +3 more sources

Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling [PDF]

Journal of Korean Neurosurgical Society, 2018
Objective Notch receptors are heterodimeric transmembrane proteins that regulate cell fate, such as differentiation, proliferation, and apoptosis.
Jun Chul Park, I. Chang, J. Ahn, Ji Hee Kim, Joon-Ho Song, S. Moon, Young-Han Park   +6 more
semanticscholar   +3 more sources

Prognostic impact of Notch1 receptor and clinicopathological High‐Risk Predictors in lacrimal gland adenoid cystic carcinoma

Acta Ophthalmologica, 2021
Adenoid Cystic Carcinoma (ACC) is an aggressive malignant lacrimal gland tumour associated with poor prognosis. Aberrant Notch signalling has been investigated in various tumours.
Shahzan Anjum, S. Sen, N. Pushker, M. Bajaj, S. Kashyap, S. Bakhshi, K. Chosdol, R. Meel, M. Sharma   +8 more
semanticscholar   +3 more sources

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

PLoS ONE, 2010
BackgroundNotch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms.
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber   +29 more
doaj   +5 more sources

Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway

International Journal of Molecular Medicine, 2017
Intestinal ischemia/reperfusion (I/R) induces disruption of the intestinal barrier function. Aryl hydrocarbon receptor (AhR) has a vital role in maintaining the intestinal barrier function. However, the precise mechanism by which AhR maintains intestinal
Zhongze Liu, Liangzi Li, Weigang Chen, Qimeng Wang, W. Xiao, Yuanhang Ma, B. Sheng, Xiang Li, Lihua Sun, Min Yu, Hua Yang   +10 more
semanticscholar   +4 more sources

G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition [PDF]

Cell Research, 2015
In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through the endothelial-to-hematopoietic transition (EHT).
Panpan Zhang, Qiuping He, Dongbo Chen, Weixiao Liu, Lu Wang, Chunxia Zhang, Dongyuan Ma, Wei Li, Bing Liu, Feng Liu   +9 more
semanticscholar   +3 more sources

Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1. [PDF]

Cancer Research, 2015
The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation.
R. Mazzieri, Giovanni Pietrogrande, L. Gerasi, A. Gandelli, P. Colombo, D. Moi, C. Brombin, A. Ambrosi, S. Danese, P. Mignatti, F. Blasi, S. D'Alessio   +11 more
semanticscholar   +5 more sources

Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways [PDF]

iScience, 2021
The anti-CD20 monoclonal antibodies rituximab and obinutuzumab differ in their mechanisms of action, with obinutuzumab evoking greater direct B cell death. To characterize the signaling processes responsible for improved B cell killing by obinutuzumab, we undertook a phosphoproteomics approach and demonstrate that rituximab and obinutuzumab ...
J. Edelmann, Arran D. Dokal, Emma Vilventhraraja, K. Holzmann, D. Britton, T. Klymenko, H. Döhner, M. Cragg, Andrejs Braun, P. Cutillas, J. Gribben   +10 more
semanticscholar   +7 more sources

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +10 more sources

Medial prefrontal cortex Notch1 signalling mediates methamphetamine-induced psychosis via Hes1-dependent suppression of GABAB1 receptor expression

bioRxiv, 2022
Methamphetamine (METH), a widely abused stimulant drug, induces psychosis in approximately half of abusers; this effect is becoming a major concern for society.
Tong Ni, Li Zhu, Shuai Wang, Weili Zhu, Y. Xue, Yingjie Zhu, Dongliang Ma, Hongyan Wang, Fanglin Guan, Teng Chen   +9 more
semanticscholar   +1 more source