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Role of Notch gene receptors as prognostic biomarkers in colorectal cancer. [PDF]
Sharma AK +8 more
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Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells. [PDF]
Marei HE +4 more
europepmc +1 more source
Methylation Landscapes of Cartilage in Hip Osteoarthritis. [PDF]
Jiang R +7 more
europepmc +1 more source
Diversity of Integration Sites of Bovine Leukemia Virus (BLV) and Roles of Genes Related to Development of BLV-Induced Lymphoma in a Large Cohort. [PDF]
Matsuura R +7 more
europepmc +1 more source
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Functional Diversity among Notch1, Notch2, and Notch3 Receptors
Biochemical and Biophysical Research Communications, 2002To clarify functional diversities among the Notch receptors, we generated truncated forms of Notch1, Notch2, and Notch3 comprising the intracellular domain (aN1, aN2, and aN3) and investigated their transcriptional activities for HES1 and HES5 promoters driving the luciferase reporter gene (HES1-Luc and HES5-Luc).
Kiyoshi, Shimizu +5 more
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Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor
ChemMedChem, 2015AbstractPrecise regulation of the Notch signaling pathway is crucial, as increases or deficiencies in signaling are associated with diseases, including a wide range of cancers. Recent studies have demonstrated that monoclonal antibodies that bind and stabilize the structure of the negative regulatory region (NRR) in the extracellular domain of the ...
Charlotte, Urech-Varenne +2 more
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Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors
Biochemical and Biophysical Research Communications, 2000The Delta/Serrate/LAG-2 (DSL) domain-containing proteins, Delta1, Jagged1, and Jagged2, are considered to be ligands for Notch receptors. However, the physical interaction between the three DSL proteins and respective Notch receptors remained largely unknown.
K, Shimizu +4 more
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