Results 221 to 230 of about 83,203 (255)
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Central nervous system myelination in mice with deficient expression of Notch1 receptor
Journal of Neuroscience Research, 2002AbstractActivity of the Notch1 gene is known to inhibit oligodendrocyte (OL) differentiation in vitro. We tested the hypothesis that the Notch1 pathway regulates in vivo myelin formation, by examining brain myelination of Notch1 receptor null heterozygotes mutant animals (Notch1+/–).
Maria I, Givogri +5 more
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Abstract 4517: Targeting Notch1 via adenosine A2A receptor to modulate tumor immunity
Cancer Research, 2020Abstract One of the hallmarks of cancer is the ability to evade the host immune system and this is achieved through different mechanisms. Several studies have showed that the accumulation of adenosine in the tumor microenvironment suppresses T-cell functions, thus helping the tumor to evade the immune system.
Giulia Monticone +12 more
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Acta Ophthalmologica, 2021
AbstractPurposeAdenoid Cystic Carcinoma (ACC) is an aggressive malignant lacrimal gland tumour associated with poor prognosis. Aberrant Notch signalling has been investigated in various tumours. However, very few studies on Notch signalling in lacrimal gland ACC are reported.
Shahzan Anjum +8 more
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AbstractPurposeAdenoid Cystic Carcinoma (ACC) is an aggressive malignant lacrimal gland tumour associated with poor prognosis. Aberrant Notch signalling has been investigated in various tumours. However, very few studies on Notch signalling in lacrimal gland ACC are reported.
Shahzan Anjum +8 more
openaire +2 more sources
Chemokine receptors as novel targets of the oncogene Notch1 in acute lymphoblastic leukemia.
Journal of Clinical Oncology, 20137060 Background: Malignant cells from different cancers express different profiles of chemokine receptors (CKR). Their presence may influence site-specific spread of tumor cells, by enabling them to respond to chemokine gradient, and may increase cell sensibility to chemokine mediated proliferative and anti-apoptotic stimuli.
L. Mirandola +16 more
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Biochemistry, 2019
Intramembrane proteases typically cleave multiple substrates within their transmembrane domains (TMDs). Because substrate TMDs lack a consensus sequence around their scissile sites, it remains unclear how the enzyme discriminates substrates from nonsubstrates at the level of their TMDs.
Walter Stelzer, Dieter Langosch
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Intramembrane proteases typically cleave multiple substrates within their transmembrane domains (TMDs). Because substrate TMDs lack a consensus sequence around their scissile sites, it remains unclear how the enzyme discriminates substrates from nonsubstrates at the level of their TMDs.
Walter Stelzer, Dieter Langosch
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Journal of Cellular Biochemistry, 2018
AbstractThere currently exists no satisfactory treatment for patients with prostate cancer with local evolution and distant metastasis. Previous studies have confirmed the importance of CC chemokine receptor 7 (CCR7) in the invasion and metastasis of prostate cancer. And increasing evidence prove that Notch1 can play diametrically opposite roles in the
Ruoyang Du +3 more
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AbstractThere currently exists no satisfactory treatment for patients with prostate cancer with local evolution and distant metastasis. Previous studies have confirmed the importance of CC chemokine receptor 7 (CCR7) in the invasion and metastasis of prostate cancer. And increasing evidence prove that Notch1 can play diametrically opposite roles in the
Ruoyang Du +3 more
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Circulation, 2008
The objective of this study was to determine whether Notch1 receptor plays a crucial role in the commitment of c-kit-positive cardiac progenitor cells (CPCs) to the myocyte lineage. This possibility was tested in the neonatal mouse heart because of the dramatic increase in the myocyte compartment early postnatally. CPCs are located within the primitive
Konrad Urbanek +11 more
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The objective of this study was to determine whether Notch1 receptor plays a crucial role in the commitment of c-kit-positive cardiac progenitor cells (CPCs) to the myocyte lineage. This possibility was tested in the neonatal mouse heart because of the dramatic increase in the myocyte compartment early postnatally. CPCs are located within the primitive
Konrad Urbanek +11 more
openaire +1 more source
Cancer Research, 2014
Abstract Tumor eradication is an elusive goal in modern medicine. This unmet goal is in part due to the imprecise therapeutic targeting of a specific population of cells having “stem-like” properties. These stem-like tumor cells can remain almost senescent during chemotherapeutic interventions to evade treatment and produce genetically ...
Elliot Pohlmann +3 more
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Abstract Tumor eradication is an elusive goal in modern medicine. This unmet goal is in part due to the imprecise therapeutic targeting of a specific population of cells having “stem-like” properties. These stem-like tumor cells can remain almost senescent during chemotherapeutic interventions to evade treatment and produce genetically ...
Elliot Pohlmann +3 more
openaire +1 more source
Biochemical Journal, 2013
The Notch receptor is necessary for modulating cell fate decisions throughout development, and aberrant activation of Notch signalling has been associated with many diseases, including tumorigenesis. The E3 ligase MDM2 (murine double minute 2) plays a role in regulating the Notch signalling pathway through its interaction with NUMB.
Susanne, Pettersson +6 more
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The Notch receptor is necessary for modulating cell fate decisions throughout development, and aberrant activation of Notch signalling has been associated with many diseases, including tumorigenesis. The E3 ligase MDM2 (murine double minute 2) plays a role in regulating the Notch signalling pathway through its interaction with NUMB.
Susanne, Pettersson +6 more
openaire +2 more sources
[Dual over-expression of P2X7 receptor and intracellular domain of Notch1 in leukemia cells].
Zhongguo shi yan xue ye xue za zhi, 2014This study aimed to construct the dual expression vectors of wide type or N187D mutant P2X7 receptor and intracellular domain of Notch1 (ICN1) linked by 2A peptide to coexpress them in leukemia cells so as to lay a foundation for further investigating the role of P2X7 in development of leukemia.
Li, Feng +7 more
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