Results 221 to 230 of about 2,402,104 (309)

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

DLL4+ neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis. [PDF]

J Clin Invest
Jin H, Holland S, Jha A, Ma G, Li J, Murao A, Aziz M, Wang P.   +7 more
europepmc   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

NOTCH1 mutation status as a prognostic biomarker in T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis. [PDF]

BMC Cancer
Al Kuwari H, Al Khinji A, Al-Hamed D, Al Hor A, Malouche D, Iqbal J.   +5 more
europepmc   +1 more source

Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol‐Induced Gastric Ulcer Rats via the Notch–Tff2 Pathway

MedComm, Volume 7, Issue 2, February 2026.
Nitrate protects the three major barriers of the gastric mucosa, alleviating bleeding and inflammation of ethanol‐induced gastric ulcer in rats, and promotes migration of gastric epithelial cells, accelerating the restoration of the ulcerated epithelium, which is strongly related to TFF2, a gastric mucosal protective factor negatively regulated by the ...
Ying Liu, Xin Wen, Yuxuan Lin, Chunmei Zhang, Jinsong Wang, Guangyong Sun, Dong Zhang, Renhong Yan, Mo Chen, Songlin Wang, Shaorong Li   +10 more
wiley   +1 more source

Notch signaling in cancer: metabolic reprogramming and therapeutic implications. [PDF]

Front Immunol
Wang SS, Lv HL, Nie RZ, Liu YP, Hou YJ, Chen C, Tao XY, Luo HM, Li PF.   +8 more
europepmc   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, Volume 7, Issue 1, February 2026.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction. [PDF]

Front Cardiovasc Med
Zhang Z, Xie F, Cheng J, Liu X, Wang X, Long J, Feng Q, Yuan D.   +7 more
europepmc   +1 more source

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 480-497, February 2026.
This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino, Juno Kim, Manru Li, Philipp Gessner, Patrick Westermann, Yagız Pat, Carina Beha, Claudia Traidl‐Hoffmann, Jeremy Bost, Nicolas Gaudenzio, Christoph B. Messner, Cezmi A. Akdis, Yasutaka Mitamura   +12 more
wiley   +1 more source

Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF. [PDF]

Int J Mol Sci
Voros C, Chatzinikolaou F, Papadimas G, Polykalas S, Koulakmanidis AM, Athanasiou D, Kanaka V, Kanaka M, Bananis K, Athanasiou A, Athanasiou A, Papapanagiotou I, Tsimpoukelis C, Daskalaki MA, Theodora M, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G.   +18 more
europepmc   +1 more source