Results 231 to 240 of about 83,203 (255)

Abstract Wed058: Silencing of Notch1 Receptor Interferes with the Electrophysiological Remodeling of the Infarcted Heart

Circulation Research
Myocardial ischemia induces re-expression of fetal genes, including Notch1 , raising the possibility that the Notch1 receptor contributes to the remodeling occurring in the injured heart. To test this hypothesis, the consequences of loss of Notch1 gene on the electrophysiological properties ...
Emanuele Pizzo, Daniel Cervantes, Andrea Filardo, Giulia Piccinini, Michael Sun, Sharanya Nair, Karen Jackson, Bhargav Vinukonda, Malik Bisserier, Jason Jacobson, Sudhir Jain, Marcello Rota   +11 more
openaire   +1 more source

[Role of Notch1 receptor on apoptosis of renal tubular epithelial cells transfected with HBx gene].

Zhonghua yi xue za zhi, 2014
To explore the expression of Notch1 receptor in renal tubular epithelial cells transfected with HBx gene and elucidate its role in cell apoptosis.The eukaryotic vector pcDNA3.1/myc-HBx containing HBx gene or vector pcDNA3.1/myc-Notch1 containing Notch1 gene was transiently transfected into HK-2 cells and shRNA technique employed for silencing Notch1 ...
Xuan, Wang, Yi, Zhou, Wei-jie, Yuan, Nan, Zhu, Ming-hua, Shang   +4 more
openaire   +1 more source

Notch1 receptor-mediated metabolic flexibility promotes a survival advantage in pancreatic neuroendocrine neoplasms

Endocrine Abstracts, 2023
Weisheng Chen, Rachael Guenter, Brendon Herring, Yuvasri Golivi, Jason Whitt, Melissa Sammy, Cole Adams, Renata Jaskula-Sztul, Herbert Chen, Bart Rose   +9 more
openaire   +1 more source

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Nature Genetics, 2023
Stefan Dentro, Michael Hall, Swee Hoe Ong   +2 more
exaly  

Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression

Systemic lupus erthematosus (SLE) is a prototype to autoimmune disease characterized by tissue deposition of autoantibody immune complex formation. However, etiology of disease remains unclaified. Defects of T lymphocytes lead to loss of immunological tolerance and support autoantibody production suggested that they may consistently have a central role
openaire   +1 more source

Endothelial Notch1 Activity Facilitates Metastasis

Cancer Cell, 2017
Juan Rodriguez-Vita, Carolin Mogler, Elisa Espinet   +2 more
exaly  

USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

Signal Transduction and Targeted Therapy, 2018
Huizhuang Shan, Yu-Ting Dai, Hu Lei
exaly  

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

Cancer Cell, 2009
Shadmehr Demehri, Raphael Kopan
exaly  

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

Nature Medicine, 2007
Teresa Palomero, Maria Ciofani, Esther Caparrós   +2 more
exaly  

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

Cancer Cell, 2013
Giovanni Roti, Anne L Carlton, Michele Markstein   +2 more
exaly