Results 231 to 240 of about 2,402,104 (309)

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source

Methylation Landscapes of Cartilage in Hip Osteoarthritis. [PDF]

Genet Res (Camb)
Jiang R, Wang M, Tan G, Lv J, Jin X, Liu Y, Wu R, Shi D.   +7 more
europepmc   +1 more source

Extraneural Metastasis in Oligodendroglioma: A Comprehensive Review and Outcome Analysis of 90 Cases

Cancer Science, Volume 117, Issue 2, Page 316-324, February 2026.
Oligodendroglioma liver metastasis. ABSTRACT Extraneural metastasis in oligodendroglioma is a rare and poorly characterized event. We report a case whereby liver and bone metastasis occurred 19 years after diagnosis. Next generation sequencing on brain and liver oligodendroglioma showed several common mutations and a few unique ones to each organ.
Ahmad Daher, Muhammad Yaman Jaber, Stefania Maraka, Hiranmayi Vemaganti, Tibor Valyi‐Nagy   +4 more
wiley   +1 more source

Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer. [PDF]

Front Nutr
Nie RZ, Wang H, Wang SS, Luo HM, Chen C, Jing ZH, Li PF.   +6 more
europepmc   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Role of Notch gene receptors as prognostic biomarkers in colorectal cancer. [PDF]

Sci Rep
Sharma AK, Nimisha N, Kumar A, Apurva A, Kumar A, Ahmad E, Ali A, Prasad B, Saluja SS.   +8 more
europepmc   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, Volume 59, Issue 2, February 2026.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Diversity of Integration Sites of Bovine Leukemia Virus (BLV) and Roles of Genes Related to Development of BLV-Induced Lymphoma in a Large Cohort. [PDF]

Int J Mol Sci
Matsuura R, Yamanaka MP, Fukushi N, Saito S, Fukumoto K, Hosomichi K, Takeshima SN, Aida Y.   +7 more
europepmc   +1 more source

PI3Kγ Deficiency Suppresses Cutaneous Squamous Cell Carcinoma Formation by Modulating the Tumour Microenvironment Rather Than by Directly Regulating Keratinocyte Proliferation

Experimental Dermatology, Volume 35, Issue 2, February 2026.
ABSTRACT Phosphatidylinositol‐3 kinase (PI3K) is a central regulator of cell proliferation, survival, metabolism, and migration via the downstream AKT/mTOR pathway. Although activating mutations in the catalytic subunit of PI3Kα (p110α) have been documented in various cancers, including cutaneous squamous cell carcinoma (cSCC), the role of PI3Kγ (p110γ)
Aya Toyoshima, Natsuko Noguchi, Tomoko Suzuki, Takako Kuroki, Masami Kagaya, Fumino Oda, Michihiro Kono, Junko Sasaki, Takehiko Sasaki, Hidehisa Saeki, Shin‐Ichi Osada   +10 more
wiley   +1 more source

Neurogenic locus notch homolog protein 1 (NOTCH 1) SNP informatics coupled with intrinsically disordered regions and post-translational modifications reveals the complex structural crosstalk of Lung Adenocarcinoma (LUAD). [PDF]

Front Bioinform
John P, Sudandiradoss C.
europepmc   +1 more source