Results 241 to 250 of about 2,402,104 (309)

WHO classification of skin tumours: key updates in the fifth edition

Histopathology, Volume 88, Issue 3, Page 555-568, February 2026.
This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy, Raymond Barnhill, Boris C. Bastian, Werner Kempf, David Elder, Pedram Gerami, Wayne Grayson, Dmitry Kazakov, Daniela Massi, Jane Messina, Arnaud de la Fouchardière, Alexander J. Lazar, Thomas Brenn, Brian Rous, Andrew Field, Anthony Gill, Jennelle C. Hodge, Joseph D Khoury, Katia Leite, Shahin Sayed, Puay Hoon Tan, Rosalie Elenitsas, Eduardo Calonje, Lyn M. Duncan, Liang Zhiyong, Holger Moch, Rajendra Singh, Harshima Wijesinghe, Ian Cree, Dilani Lokuhetty   +29 more
wiley   +1 more source

Mechanistic study of HIF-1α-mediated regulation of the Notch1 pathway in promoting radioresistance in head and neck squamous cell carcinoma: a comprehensive analysis based on bioinformatics and functional experiments. [PDF]

BMC Cancer
Bao R, Liao J.
europepmc   +1 more source

Characterising the Periodontal Granulation Tissue Using scRNAseq

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 308-320, February 2026.
ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves   +7 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Richter's transformation: status quo and quo vadis. [PDF]

Ann Hematol
Khalifa IM.
europepmc   +1 more source

Single-Cell Transcriptome Analysis of the Retina During the Development of Normal Tension Glaucoma in Mice. [PDF]

Inflammation
Liu X, Zhang D, Du M, Shao Z, Xu X, Song W, Chen S, Li X, Qiu L, Guo F, Yuan H.   +10 more
europepmc   +1 more source

Non-canonical NOTCH1 signaling regulates ferroptosis vulnerability in dormant lung cancer cells with stable resistance. [PDF]

Cell Death Dis
Huang H, Chai Y, Wu X, Wang S, Li B, Wang Y, Zheng W, Wu Y, Meng D, Wang H, Tu Z, Du C, Lyu X, Li G, Guo W.   +14 more
europepmc   +1 more source

Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience. [PDF]

Front Oncol
D'Antiga M, Serafin A, Angotzi F, Cellini A, Bevilacqua A, Leone G, Danesin N, Cavarretta CA, Piazza F, Piovan E, Bonaldi L, Trentin L, Visentin A.   +12 more
europepmc   +1 more source

DNA methylation analysis of NOTCH1 variants reveals the first episignature for non-syndromic congenital heart defects. [PDF]

Genome Med
Dombrowsky G, van der Laan L, Silva A, Breckpot J, Audain E, Wilsdon A, Levy MA, Vos N, Mannens M, Wang J, Jain A, Lesurf R, Winlaw D, Bezzina CR, Thomas MA, Caliebe A, Klaassen S, Berger F, Dittrich S, Stiller B, Abdul-Khaliq H, Dähnert I, Bu'Lock F, Loughna S, Brook JD, Mital S, Russell RB, Pickardt T, Bauer U, Kramer HH, Uebing A, Henneman P, Sadikovic B, Postma A, Hitz MP.   +34 more
europepmc   +1 more source

Functional Divergence of <i>NOTCH1</i> and <i>NOTCH2</i> in Human Cerebral Organoids Reveals Receptor-Specific Roles in Early Corticogenesis. [PDF]

Int J Mol Sci
Yakovleva S, Knyazeva A, Yunusova A, Allayarova E, Lanshakov D, Malashicheva A, Shnaider T.   +6 more
europepmc   +1 more source