Results 271 to 280 of about 2,402,104 (309)

Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor

ChemMedChem, 2015
AbstractPrecise regulation of the Notch signaling pathway is crucial, as increases or deficiencies in signaling are associated with diseases, including a wide range of cancers. Recent studies have demonstrated that monoclonal antibodies that bind and stabilize the structure of the negative regulatory region (NRR) in the extracellular domain of the ...
Charlotte Urech-Varenne, F. Radtke, C. Heinis   +2 more
semanticscholar   +3 more sources

Functional Diversity among Notch1, Notch2, and Notch3 Receptors

Biochemical and Biophysical Research Communications, 2002
To clarify functional diversities among the Notch receptors, we generated truncated forms of Notch1, Notch2, and Notch3 comprising the intracellular domain (aN1, aN2, and aN3) and investigated their transcriptional activities for HES1 and HES5 promoters driving the luciferase reporter gene (HES1-Luc and HES5-Luc).
Kiyoshi, Shimizu, Shigeru, Chiba, Toshiki, Saito, Keiki, Kumano, Yoshio, Hamada, Hisamaru, Hirai   +5 more
openaire   +2 more sources

Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors

Biochemical and Biophysical Research Communications, 2000
The Delta/Serrate/LAG-2 (DSL) domain-containing proteins, Delta1, Jagged1, and Jagged2, are considered to be ligands for Notch receptors. However, the physical interaction between the three DSL proteins and respective Notch receptors remained largely unknown.
K, Shimizu, S, Chiba, T, Saito, K, Kumano, H, Hirai   +4 more
openaire   +2 more sources

Central nervous system myelination in mice with deficient expression of Notch1 receptor

Journal of Neuroscience Research, 2002
AbstractActivity of the Notch1 gene is known to inhibit oligodendrocyte (OL) differentiation in vitro. We tested the hypothesis that the Notch1 pathway regulates in vivo myelin formation, by examining brain myelination of Notch1 receptor null heterozygotes mutant animals (Notch1+/–).
Maria I, Givogri, Rui M, Costa, Vilma, Schonmann, Alcino J, Silva, Anthony T, Campagnoni, Ernesto R, Bongarzone   +5 more
openaire   +2 more sources

Abstract 4517: Targeting Notch1 via adenosine A2A receptor to modulate tumor immunity

Cancer Research, 2020
Abstract One of the hallmarks of cancer is the ability to evade the host immune system and this is achieved through different mechanisms. Several studies have showed that the accumulation of adenosine in the tumor microenvironment suppresses T-cell functions, thus helping the tumor to evade the immune system.
Giulia Monticone, Fokhrul M. Hossain, Deniz A. Ucar, Samarpan Majumder, Claudia Sorrentino, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Silvana Morello, Lucio Miele   +12 more
openaire   +1 more source

Chemokine receptors as novel targets of the oncogene Notch1 in acute lymphoblastic leukemia.

Journal of Clinical Oncology, 2013
7060 Background: Malignant cells from different cancers express different profiles of chemokine receptors (CKR). Their presence may influence site-specific spread of tumor cells, by enabling them to respond to chemokine gradient, and may increase cell sensibility to chemokine mediated proliferative and anti-apoptotic stimuli.
L. Mirandola, M. Chiriva Internati, E. Cobos, Y. Yu, J. A. Figueroa, S. Garavelli, M. Colombo, E. Lazzari, N. Platonova, K. Zepeda, C. A. Jumper, M. Jenkins, R. Alalawi, V. Konala, A. Aulakh, S. Radhi, R. Chiaramonte   +16 more
openaire   +2 more sources

Conformationally Flexible Sites within the Transmembrane Helices of Amyloid Precursor Protein and Notch1 Receptor

Biochemistry, 2019
Intramembrane proteases typically cleave multiple substrates within their transmembrane domains (TMDs). Because substrate TMDs lack a consensus sequence around their scissile sites, it remains unclear how the enzyme discriminates substrates from nonsubstrates at the level of their TMDs.
Walter Stelzer, Dieter Langosch
openaire   +2 more sources

Abstract 3818: Notch1 Receptor Blockade Results in Dilated Cardiomyopathy in the Neonatal Mouse Heart

Circulation, 2008
The objective of this study was to determine whether Notch1 receptor plays a crucial role in the commitment of c-kit-positive cardiac progenitor cells (CPCs) to the myocyte lineage. This possibility was tested in the neonatal mouse heart because of the dramatic increase in the myocyte compartment early postnatally. CPCs are located within the primitive
Konrad Urbanek, Silvia Maestroni, Regina Lee Sohn, Francesca Delucchi, Federica Del Monte, Ronglih Liao, Sabina Signoretti, Robero Rizzi, Federico Quaini, Marcello Rota, Piero Anversa, Annarosa Leri   +11 more
openaire   +1 more source

Abstract 3862: Isolation and nanoscale visualization of glioblastoma stem-like cells utilizing the Notch1 receptor

Cancer Research, 2014
Abstract Tumor eradication is an elusive goal in modern medicine. This unmet goal is in part due to the imprecise therapeutic targeting of a specific population of cells having “stem-like” properties. These stem-like tumor cells can remain almost senescent during chemotherapeutic interventions to evade treatment and produce genetically ...
Elliot Pohlmann, Susan Murphy, Debbie Kelly, Zhi Sheng   +3 more
openaire   +1 more source

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

Biochemical Journal, 2013
The Notch receptor is necessary for modulating cell fate decisions throughout development, and aberrant activation of Notch signalling has been associated with many diseases, including tumorigenesis. The E3 ligase MDM2 (murine double minute 2) plays a role in regulating the Notch signalling pathway through its interaction with NUMB.
Susanne, Pettersson, Matylda, Sczaniecka, Lorna, McLaren, Fiona, Russell, Karen, Gladstone, Ted, Hupp, Maura, Wallace   +6 more
openaire   +2 more sources