Results 21 to 30 of about 2,402,104 (309)
Carcinogenesis, 2022 The Notch1 (Notch1 receptor) and yes-associated protein 1 (YAP1) signaling can regulate breast cancer metastasis. This study aimed at investigating whether and how these two signal pathways crosstalk to promote breast cancer lung metastasis.
Lin Zhao +11 more
semanticscholar +1 more source
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain [PDF]
Journal of Biological Chemistry, 2003 The cell fate determinant Numb influences developmental decisions by antagonizing the Notch signaling pathway. However, the underlying molecular mechanism of this inhibition is poorly understood. Here we report that the mammalian Numb protein promotes the ubiquitination of membrane-bound Notch1 receptor.
Melanie A, McGill, C Jane, McGlade
openaire +2 more sources
The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis
Scientific Reports, 2023 Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis, differentiation and proliferation. It was reported that Notch1 receptor negatively regulates mouse osteoclast development and formation by inhibiting the ...
Costanzo Padovano +12 more
doaj +1 more source
Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation. [PDF]
Neuro-Oncology, 2014 Background Notch signaling is deregulated in human gliomas and may play a role in their malignancy. However, the role of each Notch receptor in glioma cell differentiation and progression is not clear. We examined the expression pattern of Notch receptors and compared it with differentiation markers in glioma cell lines, primary human cultures, and ...
P. Dell'Albani +11 more
semanticscholar +7 more sources
Optogenetic control of NOTCH1 signaling
Cell Communication and Signaling, 2022 The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases.
Joanna Kałafut +6 more
doaj +1 more source
NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia
Frontiers in Oncology, 2022 NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).
Jennifer Edelmann
doaj +1 more source
DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation [PDF]
Journal of Biological Chemistry, 2011 DDR1 (discoidin domain receptor tyrosine kinase 1) kinase s highly expressed in a variety of human cancers and occasionally mutated in lung cancer and leukemia. It is now clear that aberrant signaling through the DDR1 receptor is closely associated with various steps of tumorigenesis, although little is known about the molecular mechanism(s) underlying
Hyung-Gu, Kim +4 more
openaire +3 more sources
Cell Death Discovery, 2022 Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li +9 more
doaj +1 more source
Notch1 signaling is limited in healthy mature kidneys in vivo
BMC Research Notes, 2023 Objective A Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1 signaling is crucial to these pathogeneses, the basal signaling level in ‘healthy’ mature ...
Ryosuke Sugiura +6 more
doaj +1 more source
Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac Anomalies [PDF]
Circulation: Cardiovascular Genetics, 2015 Background— Adams–Oliver syndrome (AOS) is a rare disorder characterized by congenital limb defects and scalp cutis aplasia. In a proportion of cases, notable cardiac involvement is also apparent. Despite recent advances in the understanding of the genetic basis of AOS, for the majority of affected subjects, the underlying ...
L. Southgate +19 more
semanticscholar +6 more sources