Results 21 to 30 of about 83,203 (255)

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation [PDF]

Neuro-Oncology, 2013
Background Notch signaling is deregulated in human gliomas and may play a role in their malignancy. However, the role of each Notch receptor in glioma cell differentiation and progression is not clear. We examined the expression pattern of Notch receptors and compared it with differentiation markers in glioma cell lines, primary human cultures, and ...
Dell'Albani P., Rodolico M, Pellitteri R., Tricarichi E., Torrisi S. A., D'Antoni S., Zappia M., Albanese V., Caltabiano R., Platania N., Aronica E., Catania M. V.   +11 more
openaire   +6 more sources

Inhibition of HDAC6 Attenuates Tumor Growth of Non-Small Cell Lung Cancer

Translational Oncology, 2020
Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through deacetylation of various cytoplasmic substrates and serves as a key member of the ubiquitin proteasome system (UPS).
Brian Deskin, Qinyan Yin, Yan Zhuang, Shigeki Saito, Bin Shan, Joseph A. Lasky   +5 more
doaj   +1 more source

CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation

Cancer Medicine, 2021
The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang   +4 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells

Scientific Reports, 2021
The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays a crucial role in angiogenesis at least in part through participating in endocytosis and, thereby, endosomal signaling of several cell surface receptors including VEGF receptor-2 ...
Shota Shimizu, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa   +3 more
doaj   +1 more source

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Notch1 and Notch2 receptors influence progressive hair graying in a dose‐dependent manner [PDF]

Developmental Dynamics, 2006
AbstractThe Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP‐Jκ, Notch1, and Notch2 conditional knockout mice.
Karine, Schouwey, Véronique, Delmas, Lionel, Larue, Ursula, Zimber-Strobl, Lothar J, Strobl, Freddy, Radtke, Friedrich, Beermann   +6 more
openaire   +2 more sources

High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma

Tumor Biology, 2017
C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong, Haiwei Wu, Zhong Guo, Tao Qin, Yang Xu, Hua Jing, Yanqing Wang, Yi Shen   +7 more
doaj   +1 more source

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS [PDF]

, 2017
No abstract ...
A de Lourdes Perim, A Kumar, AM Gomez, AP Weng, BL Asselin, CH Pui, D Passaro, JL Cannon, K Letendre, M Thome, MP Felli, MT Williams, P Van Vlierberghe, S Buonamici, Y Ma   +14 more
core   +1 more source